Prospective single-arm protocol of carvedilol in children with ventricular dysfunction

The objective of this study was to evaluate the safety and efficacy of carvedilol in pediatric patients with stable moderate heart failure. We performed a single-arm prospective drug trial at three academic medical centers and the results were compared to historical controls. Patients were 3 months...

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Veröffentlicht in:	Pediatric cardiology 2006-06, Vol.27 (3), p.336-342
Hauptverfasser:	Blume, E D, Canter, C E, Spicer, R, Gauvreau, K, Colan, S, Jenkins, K J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Carbazoles - pharmacology Carbazoles - therapeutic use Cardiac output Cardiomyopathy, Dilated - mortality Cardiomyopathy, Dilated - physiopathology Cardiomyopathy, Dilated - surgery Carvedilol Child Child, Preschool Congenital heart disease Drug therapy Evaluation Female Heart Heart failure Heart Transplantation Heart ventricles Humans Infant Male Physiological aspects Propanolamines - pharmacology Propanolamines - therapeutic use Prospective Studies Stroke Volume - drug effects Transplantation Ventricular Dysfunction, Left - drug therapy
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Beschreibung
Zusammenfassung:	The objective of this study was to evaluate the safety and efficacy of carvedilol in pediatric patients with stable moderate heart failure. We performed a single-arm prospective drug trial at three academic medical centers and the results were compared to historical controls. Patients were 3 months to 17 years old with an ejection fraction
ISSN:	0172-0643 1432-1971
DOI:	10.1007/s00246-005-1159-1