Silence from within: Endogenous siRNAs and miRNAs
Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechan...
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| Veröffentlicht in: | Cell 2005-07, Vol.122 (1), p.9-12 |
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| container_title | Cell |
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| creator | Sontheimer, Erik J. Carthew, Richard W. |
| description | Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands. |
| doi_str_mv | 10.1016/j.cell.2005.06.030 |
| format | Article |
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| ispartof | Cell, 2005-07, Vol.122 (1), p.9-12 |
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Eukaryotic Cells - cytology Eukaryotic Cells - metabolism Gene Silencing Humans MicroRNAs - genetics RNA, Small Interfering - genetics |
| title | Silence from within: Endogenous siRNAs and miRNAs |
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