Silence from within: Endogenous siRNAs and miRNAs

Silence from within: Endogenous siRNAs and miRNAs

Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechan...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell 2005-07, Vol.122 (1), p.9-12
Hauptverfasser: Sontheimer, Erik J., Carthew, Richard W.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Eukaryotic Cells - cytology
Eukaryotic Cells - metabolism
Gene Silencing
Humans
MicroRNAs - genetics
RNA, Small Interfering - genetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2005.06.030