Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells

Platelet 12-lipoxygenase (P-12-LOX) is overexpressed in different types of cancers, including prostate cancer, and the level of expression is correlated with the grade of this cancer. Arachidonic acid is metabolized by 12-LOX to 12( S )-hydroxyeicosatetraenoic acid [12( S )-HETE], and this biologica...

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Veröffentlicht in:	Molecular cancer therapeutics 2006-05, Vol.5 (5), p.1371-1382
Hauptverfasser:	Jankun, Jerzy, Aleem, Ansari M, Malgorzewicz, Sylvia, Szkudlarek, Maria, Zavodszky, Maria I, Dewitt, David L, Feig, Michael, Selman, Steven H, Skrzypczak-Jankun, Ewa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence angiogenesis Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Arachidonate 12-Lipoxygenase - chemistry Arachidonate 12-Lipoxygenase - metabolism Arachidonic Acid - metabolism Blood Platelets - cytology Blood Platelets - enzymology Cells, Cultured curcumin Curcumin - analogs & derivatives Curcumin - chemistry Curcumin - pharmacology curcuminoids Endothelial Cells - drug effects Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Humans lipoxygenase Lipoxygenase Inhibitors Mice Models, Molecular Molecular Sequence Data prostate cancer
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