Electrochemical SNPs detection using an abasic site-containing DNA on a gold electrode

Electrochemical SNPs detection using an abasic site-containing DNA on a gold electrode

An abasic site-containing DNA combined with lumiflavin allows amperometric determination of single nucleotide polymorphism through hydrogen bond-mediated nucleobase recognition in water by using abasic sites as a molecular recognition field.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2006-01 (22), p.2376-2378
Hauptverfasser: Morita, Kotaro, Sankaran, N B, Huang, Weimin, Seino, Takehiro, Sato, Yusuke, Nishizawa, Seiichi, Teramae, Norio
Format: Artikel
Sprache:eng
Schlagworte:
Base Pairing
Binding Sites
DNA - chemistry
Electrochemistry
Electrodes
Flavins - chemistry
Gold - chemistry
Hydrogen Bonding
Ligands
Polymorphism, Single Nucleotide
Surface Properties
Water - chemistry
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Beschreibung
Zusammenfassung:An abasic site-containing DNA combined with lumiflavin allows amperometric determination of single nucleotide polymorphism through hydrogen bond-mediated nucleobase recognition in water by using abasic sites as a molecular recognition field.
ISSN:1359-7345
1364-548X
DOI:10.1039/b517391d