Correlation of reactive oxygen species levels with the fertilization rate after in vitro fertilization: A qualified meta-analysis

Our meta-analysis analyzed the relationship between levels of reactive oxygen species (ROS) and fertilization rate after in vitro fertilization (IVF), and showed a statistically significant correlation between the ROS levels and the IVF fertilization rate (estimated overall correlation −0.374 [95% C...

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Veröffentlicht in:	Fertility and sterility 2005-07, Vol.84 (1), p.228-231
Hauptverfasser:	Agarwal, Ashok, Allamaneni, Shyam S.R., Nallella, Kiran P., George, Amanda T., Mascha, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Confidence Intervals Female Fertilization in Vitro - statistics & numerical data Gynecology. Andrology. Obstetrics Humans Infertility - metabolism Male Medical sciences Reactive Oxygen Species - analysis Reactive Oxygen Species - metabolism Regression Analysis
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Zusammenfassung:	Our meta-analysis analyzed the relationship between levels of reactive oxygen species (ROS) and fertilization rate after in vitro fertilization (IVF), and showed a statistically significant correlation between the ROS levels and the IVF fertilization rate (estimated overall correlation −0.374 [95% CI, −0.520, −0.205]). We conclude that ROS has a statistically significant effect on the fertilization rate after IVF, and that the measurement of ROS levels in semen specimens before IVF may be useful in predicting the IVF outcome and in counseling patients.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2004.12.057