Energy Deregulation: Licensing Tumors to Grow

Taking their cue from a controversial, 80-year-old theory of cancer, scientists are reexamining how tumors fuel their own growth and finding new ways to cut off their energy supply.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2006-05, Vol.312 (5777), p.1158-1159
1. Verfasser:	Garber, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use ATP Citrate (pro-S)-Lyase - antagonists & inhibitors ATP Citrate (pro-S)-Lyase - metabolism Biology Cancer Cell Respiration Cell Transformation, Neoplastic Cellular metabolism Energy Metabolism Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzymes Glucose - metabolism Glycolysis Hexokinase - antagonists & inhibitors Hexokinase - metabolism Humans Hypoxia-Inducible Factor 1 - metabolism Models, Biological Molecules Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology News Oxygen Positron emission tomography Protein Kinases - metabolism Protein-Serine-Threonine Kinases Proto-Oncogene Proteins c-akt - metabolism Respiration Theory Tumors
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Beschreibung
Zusammenfassung:	Taking their cue from a controversial, 80-year-old theory of cancer, scientists are reexamining how tumors fuel their own growth and finding new ways to cut off their energy supply.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.312.5777.1158