Synthesis and biological evaluation of novel angularly fused polycyclic coumarins

Novel angularly fused pentacyclic heterocycles with coumarin and benzofuran fused to the pyridine ring were synthesized and show promising anti-inflammatory activities. In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.