Prodrug Activation Gated by a Molecular "OR" Logic Trigger

Molecules that define logic: A molecular “OR” logic gate trigger has been demonstrated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see sche...

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Veröffentlicht in:	Angewandte Chemie International Edition 2005-07, Vol.44 (28), p.4378-4381
Hauptverfasser:	Amir, Roey J., Popkov, Mikhail, Lerner, Richard A., Barbas III, Carlos F., Shabat, Doron
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry catalytic antibodies Cell Line, Tumor Cell Proliferation - drug effects Chromatography, High Pressure Liquid Doxorubicin - chemistry drug delivery Drug Screening Assays, Antitumor enzymes Fructose-Bisphosphate Aldolase - chemistry Fructose-Bisphosphate Aldolase - pharmacology Humans Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - pharmacology Logic logic gates Models, Biological Penicillin Amidase - chemistry Penicillin Amidase - pharmacology prodrugs Prodrugs - chemistry Prodrugs - pharmacology
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Beschreibung
Zusammenfassung:	Molecules that define logic: A molecular “OR” logic gate trigger has been demonstrated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200500842