Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype
Background: Folic acid reduces plasma homocysteine and may be an important therapy for preventing cardiovascular disease. A key mechanism may be the reduction of arterial stiffness. Objective: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relat...
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| Veröffentlicht in: | The American journal of clinical nutrition 2005-07, Vol.82 (1), p.26-31 |
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| creator | Williams, C Kingwell, B.A Burke, K McPherson, J Dart, A.M |
| description | Background: Folic acid reduces plasma homocysteine and may be an important therapy for preventing cardiovascular disease. A key mechanism may be the reduction of arterial stiffness. Objective: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relation to methylenetetrahydrofolate reductase (MTHFR) genotype. Design: Forty-one asymptomatic men with normal or high-normal ambulatory blood pressure (systolic: >130 to 80 to |
| doi_str_mv | 10.1093/ajcn/82.1.26 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68012523</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>876799801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-6d97ed948c3246cc720fce2b82d6d3bf2c384b2c0c72c900c305f3d025b2a91d3</originalsourceid><addsrcrecordid>eNpd0c9rFDEUB_Agil2rN88aBD0525eXmWxyLMW1QkXQ9hwy-bHMOpuMyQyy_70pu6B4SQLfD1_Ce4S8ZrBmoPiV2dt4JXHN1iiekBVTXDYcYfOUrAAAG8VEd0FelLIHYNhK8ZxcMFGTjRIrUrZpHCw1dnC0LNM0-oOPs5mHFGlImXL6-yfN3i3WFzotY_F0yr6UJXtqoqOjybv6yrPPR1rmIYRYUzpE5ydfjzjTFOjX-9vtd7rzMc3Hyb8kz4KpTa_O9yV52H66v7lt7r59_nJzfddYLrq5EU5tvFOttBxbYe0GIViPvUQnHO8DWi7bHi3UxCoAy6EL3AF2PRrFHL8kH069U06_Fl9mfRiK9eNook9L0ULWgXTIK3z3H9ynJcf6N42cqRaZaCv6eEI2p1KyD3rKw8Hko2agHzehHzehJWqmUVT-5ty59Afv_uLz6Ct4fwamWDOGbKIdyj9OdQgSq3t7csEkbXa5mocfCIwDA0RQjP8BaRmbEw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>231942164</pqid></control><display><type>article</type><title>Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Williams, C ; Kingwell, B.A ; Burke, K ; McPherson, J ; Dart, A.M</creator><creatorcontrib>Williams, C ; Kingwell, B.A ; Burke, K ; McPherson, J ; Dart, A.M</creatorcontrib><description>Background: Folic acid reduces plasma homocysteine and may be an important therapy for preventing cardiovascular disease. A key mechanism may be the reduction of arterial stiffness. Objective: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relation to methylenetetrahydrofolate reductase (MTHFR) genotype. Design: Forty-one asymptomatic men with normal or high-normal ambulatory blood pressure (systolic: >130 to <145 mm Hg; diastolic: >80 to <90 mm Hg) participated. The study had a randomized, placebo-controlled, double-blind, crossover design that incorporated 3-wk treatments with 5 mg folic acid/d or matching placebo; each treatment was separated by a 4-wk washout phase. Results: Folic acid reduced brachial pulse pressure by 4.7 +/- 1.6 mm Hg (P < 0.05) without changing mean arterial pressure. Systemic arterial compliance increased by 0.15 +/- 0.03 mL/mm Hg (P < 0.05) after folic acid treatment but did not change after placebo treatment. These responses did not significantly correlate with either homocysteine or folate plasma concentrations. MTHFR genotype CC homozygotes (without the 677C leads to T polymorphism) with normal blood pressure had a larger reduction in homocysteine concentrations in response to folic acid than did T allele carriers. Blood pressure and arterial stiffness responses were independent of MTHFR genotype. Conclusion: Folic acid is a safe and effective supplement that targets large artery stiffness and may prevent isolated systolic hypertension.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/82.1.26</identifier><identifier>PMID: 16002796</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Adult ; arteries ; Biological and medical sciences ; Blood Glucose - drug effects ; Blood pressure ; Blood Pressure - drug effects ; Blood vessels ; cardioprotective effect ; cardiovascular diseases ; Cholesterol - blood ; Cross-Over Studies ; Diet ; Dietary supplements ; Double-Blind Method ; Feeding. Feeding behavior ; folic acid ; Folic Acid - administration & dosage ; Folic Acid - blood ; Folic Acid - therapeutic use ; Fundamental and applied biological sciences. Psychology ; genes ; genetics ; Genotype ; Genotype & phenotype ; Hematinics - administration & dosage ; Hematinics - blood ; Hematinics - therapeutic use ; hemodynamics ; homocysteine ; Humans ; Hyperhomocysteinemia - drug therapy ; Hypertension ; Hypertension - drug therapy ; Male ; men ; methylenetetrahydrofolate reductase ; methylenetetrahydrofolate reductase (MTHFR) ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; nutritional intervention ; systolic blood pressure ; Vascular Resistance - drug effects ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin B ; vitamin supplements</subject><ispartof>The American journal of clinical nutrition, 2005-07, Vol.82 (1), p.26-31</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jul 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c365t-6d97ed948c3246cc720fce2b82d6d3bf2c384b2c0c72c900c305f3d025b2a91d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16952082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16002796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, C</creatorcontrib><creatorcontrib>Kingwell, B.A</creatorcontrib><creatorcontrib>Burke, K</creatorcontrib><creatorcontrib>McPherson, J</creatorcontrib><creatorcontrib>Dart, A.M</creatorcontrib><title>Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Background: Folic acid reduces plasma homocysteine and may be an important therapy for preventing cardiovascular disease. A key mechanism may be the reduction of arterial stiffness. Objective: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relation to methylenetetrahydrofolate reductase (MTHFR) genotype. Design: Forty-one asymptomatic men with normal or high-normal ambulatory blood pressure (systolic: >130 to <145 mm Hg; diastolic: >80 to <90 mm Hg) participated. The study had a randomized, placebo-controlled, double-blind, crossover design that incorporated 3-wk treatments with 5 mg folic acid/d or matching placebo; each treatment was separated by a 4-wk washout phase. Results: Folic acid reduced brachial pulse pressure by 4.7 +/- 1.6 mm Hg (P < 0.05) without changing mean arterial pressure. Systemic arterial compliance increased by 0.15 +/- 0.03 mL/mm Hg (P < 0.05) after folic acid treatment but did not change after placebo treatment. These responses did not significantly correlate with either homocysteine or folate plasma concentrations. MTHFR genotype CC homozygotes (without the 677C leads to T polymorphism) with normal blood pressure had a larger reduction in homocysteine concentrations in response to folic acid than did T allele carriers. Blood pressure and arterial stiffness responses were independent of MTHFR genotype. Conclusion: Folic acid is a safe and effective supplement that targets large artery stiffness and may prevent isolated systolic hypertension.</description><subject>Adult</subject><subject>arteries</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Blood vessels</subject><subject>cardioprotective effect</subject><subject>cardiovascular diseases</subject><subject>Cholesterol - blood</subject><subject>Cross-Over Studies</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Double-Blind Method</subject><subject>Feeding. Feeding behavior</subject><subject>folic acid</subject><subject>Folic Acid - administration & dosage</subject><subject>Folic Acid - blood</subject><subject>Folic Acid - therapeutic use</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genes</subject><subject>genetics</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Hematinics - administration & dosage</subject><subject>Hematinics - blood</subject><subject>Hematinics - therapeutic use</subject><subject>hemodynamics</subject><subject>homocysteine</subject><subject>Humans</subject><subject>Hyperhomocysteinemia - drug therapy</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Male</subject><subject>men</subject><subject>methylenetetrahydrofolate reductase</subject><subject>methylenetetrahydrofolate reductase (MTHFR)</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>nutritional intervention</subject><subject>systolic blood pressure</subject><subject>Vascular Resistance - drug effects</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin B</subject><subject>vitamin supplements</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c9rFDEUB_Agil2rN88aBD0525eXmWxyLMW1QkXQ9hwy-bHMOpuMyQyy_70pu6B4SQLfD1_Ce4S8ZrBmoPiV2dt4JXHN1iiekBVTXDYcYfOUrAAAG8VEd0FelLIHYNhK8ZxcMFGTjRIrUrZpHCw1dnC0LNM0-oOPs5mHFGlImXL6-yfN3i3WFzotY_F0yr6UJXtqoqOjybv6yrPPR1rmIYRYUzpE5ydfjzjTFOjX-9vtd7rzMc3Hyb8kz4KpTa_O9yV52H66v7lt7r59_nJzfddYLrq5EU5tvFOttBxbYe0GIViPvUQnHO8DWi7bHi3UxCoAy6EL3AF2PRrFHL8kH069U06_Fl9mfRiK9eNook9L0ULWgXTIK3z3H9ynJcf6N42cqRaZaCv6eEI2p1KyD3rKw8Hko2agHzehHzehJWqmUVT-5ty59Afv_uLz6Ct4fwamWDOGbKIdyj9OdQgSq3t7csEkbXa5mocfCIwDA0RQjP8BaRmbEw</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Williams, C</creator><creator>Kingwell, B.A</creator><creator>Burke, K</creator><creator>McPherson, J</creator><creator>Dart, A.M</creator><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype</title><author>Williams, C ; Kingwell, B.A ; Burke, K ; McPherson, J ; Dart, A.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-6d97ed948c3246cc720fce2b82d6d3bf2c384b2c0c72c900c305f3d025b2a91d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>arteries</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Blood vessels</topic><topic>cardioprotective effect</topic><topic>cardiovascular diseases</topic><topic>Cholesterol - blood</topic><topic>Cross-Over Studies</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Double-Blind Method</topic><topic>Feeding. Feeding behavior</topic><topic>folic acid</topic><topic>Folic Acid - administration & dosage</topic><topic>Folic Acid - blood</topic><topic>Folic Acid - therapeutic use</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genes</topic><topic>genetics</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Hematinics - administration & dosage</topic><topic>Hematinics - blood</topic><topic>Hematinics - therapeutic use</topic><topic>hemodynamics</topic><topic>homocysteine</topic><topic>Humans</topic><topic>Hyperhomocysteinemia - drug therapy</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Male</topic><topic>men</topic><topic>methylenetetrahydrofolate reductase</topic><topic>methylenetetrahydrofolate reductase (MTHFR)</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>nutritional intervention</topic><topic>systolic blood pressure</topic><topic>Vascular Resistance - drug effects</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin B</topic><topic>vitamin supplements</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, C</creatorcontrib><creatorcontrib>Kingwell, B.A</creatorcontrib><creatorcontrib>Burke, K</creatorcontrib><creatorcontrib>McPherson, J</creatorcontrib><creatorcontrib>Dart, A.M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, C</au><au>Kingwell, B.A</au><au>Burke, K</au><au>McPherson, J</au><au>Dart, A.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>82</volume><issue>1</issue><spage>26</spage><epage>31</epage><pages>26-31</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Background: Folic acid reduces plasma homocysteine and may be an important therapy for preventing cardiovascular disease. A key mechanism may be the reduction of arterial stiffness. Objective: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relation to methylenetetrahydrofolate reductase (MTHFR) genotype. Design: Forty-one asymptomatic men with normal or high-normal ambulatory blood pressure (systolic: >130 to <145 mm Hg; diastolic: >80 to <90 mm Hg) participated. The study had a randomized, placebo-controlled, double-blind, crossover design that incorporated 3-wk treatments with 5 mg folic acid/d or matching placebo; each treatment was separated by a 4-wk washout phase. Results: Folic acid reduced brachial pulse pressure by 4.7 +/- 1.6 mm Hg (P < 0.05) without changing mean arterial pressure. Systemic arterial compliance increased by 0.15 +/- 0.03 mL/mm Hg (P < 0.05) after folic acid treatment but did not change after placebo treatment. These responses did not significantly correlate with either homocysteine or folate plasma concentrations. MTHFR genotype CC homozygotes (without the 677C leads to T polymorphism) with normal blood pressure had a larger reduction in homocysteine concentrations in response to folic acid than did T allele carriers. Blood pressure and arterial stiffness responses were independent of MTHFR genotype. Conclusion: Folic acid is a safe and effective supplement that targets large artery stiffness and may prevent isolated systolic hypertension.</abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>16002796</pmid><doi>10.1093/ajcn/82.1.26</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult arteries Biological and medical sciences Blood Glucose - drug effects Blood pressure Blood Pressure - drug effects Blood vessels cardioprotective effect cardiovascular diseases Cholesterol - blood Cross-Over Studies Diet Dietary supplements Double-Blind Method Feeding. Feeding behavior folic acid Folic Acid - administration & dosage Folic Acid - blood Folic Acid - therapeutic use Fundamental and applied biological sciences. Psychology genes genetics Genotype Genotype & phenotype Hematinics - administration & dosage Hematinics - blood Hematinics - therapeutic use hemodynamics homocysteine Humans Hyperhomocysteinemia - drug therapy Hypertension Hypertension - drug therapy Male men methylenetetrahydrofolate reductase methylenetetrahydrofolate reductase (MTHFR) Methylenetetrahydrofolate Reductase (NADPH2) - genetics nutritional intervention systolic blood pressure Vascular Resistance - drug effects Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin B vitamin supplements |
| title | Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype |
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