Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype

Background: Folic acid reduces plasma homocysteine and may be an important therapy for preventing cardiovascular disease. A key mechanism may be the reduction of arterial stiffness. Objective: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relat...

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Veröffentlicht in:	The American journal of clinical nutrition 2005-07, Vol.82 (1), p.26-31
Hauptverfasser:	Williams, C, Kingwell, B.A, Burke, K, McPherson, J, Dart, A.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult arteries Biological and medical sciences Blood Glucose - drug effects Blood pressure Blood Pressure - drug effects Blood vessels cardioprotective effect cardiovascular diseases Cholesterol - blood Cross-Over Studies Diet Dietary supplements Double-Blind Method Feeding. Feeding behavior folic acid Folic Acid - administration & dosage Folic Acid - blood Folic Acid - therapeutic use Fundamental and applied biological sciences. Psychology genes genetics Genotype Genotype & phenotype Hematinics - administration & dosage Hematinics - blood Hematinics - therapeutic use hemodynamics homocysteine Humans Hyperhomocysteinemia - drug therapy Hypertension Hypertension - drug therapy Male men methylenetetrahydrofolate reductase methylenetetrahydrofolate reductase (MTHFR) Methylenetetrahydrofolate Reductase (NADPH2) - genetics nutritional intervention systolic blood pressure Vascular Resistance - drug effects Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin B vitamin supplements
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Zusammenfassung:	Background: Folic acid reduces plasma homocysteine and may be an important therapy for preventing cardiovascular disease. A key mechanism may be the reduction of arterial stiffness. Objective: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relation to methylenetetrahydrofolate reductase (MTHFR) genotype. Design: Forty-one asymptomatic men with normal or high-normal ambulatory blood pressure (systolic: >130 to 80 to
ISSN:	0002-9165 1938-3207
DOI:	10.1093/ajcn/82.1.26