FR227673 and FR190293, novel antifungal lipopeptides from Chalara sp. No. 22210 and tolypocladium parasiticum No. 16616

Novel antifungal lipopeptides, FR227673 and FR190293, were isolated from the fermentation broths of fungal strains Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616, respectively. These compounds have the same cyclic peptide nuclear structure as FR901379, with different side chains, and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 2006-03, Vol.59 (3), p.158-167
Hauptverfasser:	Kanasaki, Ryuichi, Kobayashi, Motoo, Fujine, Kiyotaka, Sato, Ikuko, Hashimoto, Michizane, Takase, Shigehiro, Tsurumi, Yasuhisa, Fujie, Akihiko, Hino, Motohiro, Hashimoto, Seiji, Hori, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Aspergillus fumigatus Aspergillus fumigatus - drug effects Candida albicans Candida albicans - drug effects Chalara Fermentation Lipoproteins - chemistry Lipoproteins - isolation & purification Lipoproteins - pharmacology Mitosporic Fungi - classification Mitosporic Fungi - metabolism Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Tolypocladium
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Novel antifungal lipopeptides, FR227673 and FR190293, were isolated from the fermentation broths of fungal strains Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616, respectively. These compounds have the same cyclic peptide nuclear structure as FR901379, with different side chains, and showed antifungal activity against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1,3-beta-glucan synthesis.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2006.23