Enzyme-cleavable linkers for peptide and glycopeptide synthesis

Enzyme-cleavable linkers for peptide and glycopeptide synthesis

Hydroxymethylphenoxy linkers that are commonly used in solid phase peptide synthesis are surprisingly susceptible to efficient cleavage by the protease chymotrypsin with a broad range of amino acid residues being tolerated at the scissile bond; this enzyme-cleavable linker system has been applied to...

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Veröffentlicht in:Organic & biomolecular chemistry 2005-07, Vol.3 (14), p.2505-2507
Hauptverfasser: Maltman, Beatrice A, Bejugam, Mallesham, Flitsch, Sabine L
Format: Artikel
Sprache:eng
Schlagworte:
Chymotrypsin - chemistry
Chymotrypsin - metabolism
Combinatorial Chemistry Techniques - methods
Cross-Linking Reagents - chemistry
Glycopeptides - chemical synthesis
Glycopeptides - chemistry
Hydrolysis
Molecular Structure
Peptides - chemical synthesis
Peptides - chemistry
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Zusammenfassung:Hydroxymethylphenoxy linkers that are commonly used in solid phase peptide synthesis are surprisingly susceptible to efficient cleavage by the protease chymotrypsin with a broad range of amino acid residues being tolerated at the scissile bond; this enzyme-cleavable linker system has been applied to peptide and glycopeptide synthesis.
ISSN:1477-0520
1477-0539
DOI:10.1039/b506154g