Family-Based Association Analysis of Hepatocyte Growth Factor (HGF) Gene Polymorphisms in High Myopia

To investigate the association of high myopia with polymorphisms in the hepatocyte growth factor (HGF) gene, a potential candidate for myopia development. Single nucleotide polymorphisms (SNPs) were screened and identified in the HGF gene region with denaturing high-performance liquid chromatography...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2006-06, Vol.47 (6), p.2291-2299
Hauptverfasser:	Han, Wei, Yap, Maurice K. H, Wang, Jing, Yip, Shea Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Chromatography, High Pressure Liquid Eye and associated structures. Visual pathways and centers. Vision Family Health Female Fluorescence Polarization Fundamental and applied biological sciences. Psychology Genotype Hepatocyte Growth Factor - genetics Humans Linkage Disequilibrium Male Medical sciences Myopia, Degenerative - genetics Ophthalmology Polymerase Chain Reaction Polymorphism, Single Nucleotide Vertebrates: nervous system and sense organs Vision disorders
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Beschreibung
Zusammenfassung:	To investigate the association of high myopia with polymorphisms in the hepatocyte growth factor (HGF) gene, a potential candidate for myopia development. Single nucleotide polymorphisms (SNPs) were screened and identified in the HGF gene region with denaturing high-performance liquid chromatography, and their linkage disequilibrium pattern was established in a Han Chinese population (n=150). Tag SNPs were selected and genotyped using restriction digestion and fluorescence polarization assays for 128 nuclear families with 133 severely myopic (mean spherical equivalent [MSE]
ISSN:	0146-0404 1552-5783 1552-5783
DOI:	10.1167/iovs.05-1344