Induction of G0/G1 Arrest and Apoptosis by 3-Hydroxycinnamic Acid in Human Cervix Epithelial Carcinoma (HeLa) Cells

The present studies were undertaken to analyze the factors regulating 3-hydroxycinnamic acid-induced apoptosis and cell cycle arrest. Treatment of human cervix HeLa cells with 3-hydroxycinnamic acid induced apoptosis and G 0 /G 1 -phase arrest. The percentage of apoptosis induced by 3-hydroxycinnami...

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Veröffentlicht in:	In vivo (Athens) 2005-07, Vol.19 (4), p.683-688
Hauptverfasser:	Chuang, Jing-Yuan, Tsai, Yueh-Yu, Chen, Ssu-Ching, Hsieh, Tian-Jye, Chung, Jing-Gung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Apoptosis - drug effects bcl-2-Associated X Protein Caspase 3 Caspases - metabolism Cell Proliferation - drug effects Cell Survival - drug effects Coumaric Acids - pharmacology Cyclin B - metabolism DNA Fragmentation - drug effects Dose-Response Relationship, Drug Female G1 Phase - drug effects HeLa Cells - drug effects HeLa Cells - metabolism HeLa Cells - pathology Humans Proto-Oncogene Proteins c-bcl-2 - metabolism Resting Phase, Cell Cycle - drug effects Tumor Suppressor Protein p53 - metabolism Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
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Zusammenfassung:	The present studies were undertaken to analyze the factors regulating 3-hydroxycinnamic acid-induced apoptosis and cell cycle arrest. Treatment of human cervix HeLa cells with 3-hydroxycinnamic acid induced apoptosis and G 0 /G 1 -phase arrest. The percentage of apoptosis induced by 3-hydroxycinnamic acid in HeLa cells was increased with incubation time. The results also demonstrated that 3-hydroxycinnamic acid increased the expression of p53, caspase-3, Bax and cyclin B. These results demonstrated that 3-hydroxycinnamic acid induced apoptosis through p53- and caspase-3-dependent pathways.
ISSN:	0258-851X 1791-7549