Tetraarylporphyrin as a Selective Molecular Cap for Non-Watson-Crick Guanine-Adenine Base-Pair Sequences

Tetraarylporphyrin as a Selective Molecular Cap for Non-Watson-Crick Guanine-Adenine Base-Pair Sequences

Well protected: Porphyrins act as a molecular cap (see picture) to selectively stabilize a non‐self‐complementary non‐Watson–Crick DNA structure through additional hydrophobic interactions. At the same time, these porphyrins serve as an efficient internal sensor of the newly formed secondary structu...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-05, Vol.45 (21), p.3530-3533
Hauptverfasser: Balaz, Milan, Li, Benjamin C., Jockusch, Steffen, Ellestad, George A., Berova, Nina
Format: Artikel
Sprache:eng
Schlagworte:
Adenine - chemistry
Base Pairing
Base Sequence
Circular Dichroism
DNA structures
fluorescence
Guanine - chemistry
Hydrogen Bonding
mismatched base pairs
Nucleic Acid Conformation
porphyrinoids
Porphyrins - chemistry
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Beschreibung
Zusammenfassung:Well protected: Porphyrins act as a molecular cap (see picture) to selectively stabilize a non‐self‐complementary non‐Watson–Crick DNA structure through additional hydrophobic interactions. At the same time, these porphyrins serve as an efficient internal sensor of the newly formed secondary structure.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200504431