Tritiation of imipramine and pseudo irreversible analogues 3-Cyanoimipramine and 2-Nitroimipramine at high specific activity

Methods are presented to synthesize and characterize [N-methyl- 3H] imipramine 3, [N-methyl- 3H] 3-cyanoimipramine 6 and [N-methyl- 3H] 2-nitroimipramine 9.

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Bibliographische Detailangaben
Veröffentlicht in:	Applied radiation and isotopes 2006-07, Vol.64 (7), p.798-801
Hauptverfasser:	Ahern, David G., Johnson, Eileen, Laseter, Anne G., Filer, Crist N.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Nitrodesipramine 2-Nitroimipramine 3-Cyanoimipramine Antidepressive Agents, Tricyclic - chemical synthesis Antidepressive Agents, Tricyclic - chemistry Imipramine Imipramine - analogs & derivatives Imipramine - chemical synthesis Imipramine - chemistry Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Tritium Tritium - chemistry
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Beschreibung
Zusammenfassung:	Methods are presented to synthesize and characterize [N-methyl- 3H] imipramine 3, [N-methyl- 3H] 3-cyanoimipramine 6 and [N-methyl- 3H] 2-nitroimipramine 9.
ISSN:	0969-8043 1872-9800
DOI:	10.1016/j.apradiso.2006.01.017