Titanium-Salan-Catalyzed Asymmetric Epoxidation with Aqueous Hydrogen Peroxide as the Oxidant

Titanium-Salan-Catalyzed Asymmetric Epoxidation with Aqueous Hydrogen Peroxide as the Oxidant

Keep it simple: A titanium complex with a salan ligand bearing phenyl groups at C3 and C3′ is an efficient catalyst for the enantioselective epoxidation of unfunctionalized olefins with aqueous hydrogen peroxide (see scheme); furthermore, the epoxidation was stereospecific. The C3 and C3′ substituen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2006-05, Vol.45 (21), p.3478-3480
Hauptverfasser: Sawada, Yuji, Matsumoto, Kazuhiro, Kondo, Shoichi, Watanabe, Hisayuki, Ozawa, Tomoyuki, Suzuki, Kenji, Saito, Bunnai, Katsuki, Tsutomu
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
enantioselectivity
epoxidation
hydrogen peroxide
titanium
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Keep it simple: A titanium complex with a salan ligand bearing phenyl groups at C3 and C3′ is an efficient catalyst for the enantioselective epoxidation of unfunctionalized olefins with aqueous hydrogen peroxide (see scheme); furthermore, the epoxidation was stereospecific. The C3 and C3′ substituents stabilize this complex and enhance the asymmetric induction.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200600636