A Nickel-Alkyl Bond in an Inactivated State of the Enzyme Catalyzing Methane Formation

The spin reveals all: Electron paramagnetic resonance spectroscopy reveals the formation of a nickel–alkyl bond in the active site of methyl‐coenzyme M reductase (MCR), the key enzyme of methanogenesis, when active MCRred1 reacts with the irreversible inhibitor 3‐bromopropane sulfonate to form the M...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2006-05, Vol.45 (22), p.3602-3607
Hauptverfasser:	Hinderberger, Dariush, Piskorski, Rafal P., Goenrich, Meike, Thauer, Rudolf K., Schweiger, Arthur, Harmer, Jeffrey, Jaun, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanesulfonic Acids - chemistry bioinorganic chemistry Catalysis Electron Spin Resonance Spectroscopy enzymes EPR spectroscopy Methane - chemistry methanogenesis nickel Nickel - chemistry Oxidoreductases - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The spin reveals all: Electron paramagnetic resonance spectroscopy reveals the formation of a nickel–alkyl bond in the active site of methyl‐coenzyme M reductase (MCR), the key enzyme of methanogenesis, when active MCRred1 reacts with the irreversible inhibitor 3‐bromopropane sulfonate to form the MCRBPS species.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200600366