Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients

Objective. To obtain a global view of the immunological alterations occurring in early systemic sclerosis (SSc) by transcriptional profiling of peripheral blood cells (PBCs). Methods. Oligonucleotide microarrays were used to compare PBC gene expression profiles in 18 SSc cases (

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Bibliographische Detailangaben
Veröffentlicht in:	Rheumatology (Oxford, England) England), 2006-06, Vol.45 (6), p.694-702
Hauptverfasser:	Tan, F. K., Zhou, X., Mayes, M. D., Gourh, P., Guo, X., Marcum, C., Jin, L., Arnett, F. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autoimmunity Autoimmunity - genetics Biological and medical sciences Blood cells Blood Cells - metabolism Cell Adhesion Molecules - blood Cell Adhesion Molecules - genetics Diseases of the osteoarticular system Endothelium, Vascular - metabolism Female Gene Expression Profiling - methods Gene Expression Regulation - immunology Human Humans Interferons - blood Interferons - genetics Male Medical sciences Microarrays Middle Aged Multigene Family Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction - methods Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - blood Scleroderma, Systemic - genetics Scleroderma, Systemic - immunology Signal Transduction - genetics Systemic sclerosis
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Beschreibung
Zusammenfassung:	Objective. To obtain a global view of the immunological alterations occurring in early systemic sclerosis (SSc) by transcriptional profiling of peripheral blood cells (PBCs). Methods. Oligonucleotide microarrays were used to compare PBC gene expression profiles in 18 SSc cases (
ISSN:	1462-0324 1462-0332
DOI:	10.1093/rheumatology/kei244