Immunological Response to Highly Active Antiretroviral Therapy in Children with Clinically Stable HIV-1 Infection

We studied changes in 60 immunological parameters after the administration of highly active antiretroviral therapy (HAART) in 192 clinically stable antiretroviral drug–experienced HIV-1–infected children 4 months–17 years old. The studied immunological parameters included standard lymphocyte subsets...

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Veröffentlicht in:	The Journal of infectious diseases 2005-08, Vol.192 (3), p.445-455
Hauptverfasser:	Rosenblatt, Howard M., Stanley, Kenneth E., Song, Lin Y., Johnson, George M., Wiznia, Andrew A., Nachman, Sharon A., Krogstad, Paul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - immunology AIDS Antigens, CD - blood Antiretroviral Therapy, Highly Active Antiretrovirals Biological and medical sciences CD4 Lymphocyte Count CD8-Positive T-Lymphocytes - immunology Child Flow Cytometry Fundamental and applied biological sciences. Psychology Highly active antiretroviral therapy HIV 1 HIV Infections - drug therapy HIV Infections - immunology HIV/AIDS HLA-DR Antigens - blood Human immunodeficiency virus 1 Human viral diseases Humans Immunology Infections Infectious diseases Lymphocyte Activation Lymphocyte Count Lymphocytes Medical sciences Microbiology Miscellaneous Pediatrics RNA T lymphocytes T-Lymphocytes - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology
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Zusammenfassung:	We studied changes in 60 immunological parameters after the administration of highly active antiretroviral therapy (HAART) in 192 clinically stable antiretroviral drug–experienced HIV-1–infected children 4 months–17 years old. The studied immunological parameters included standard lymphocyte subsets and lymphocyte surface markers of maturation and activation. The most significant changes during the 48-week study period were seen for CD8+, CD8+CD62L+CD45RA+, CD8+CD38+HLA-DR+, and CD4+ T cell percentages (P
ISSN:	0022-1899 1537-6613
DOI:	10.1086/431597