The Polyol Domain of Amphidinol 3. A Stereoselective Synthesis of the Entire C(1)−C(30) Sector

The Polyol Domain of Amphidinol 3. A Stereoselective Synthesis of the Entire C(1)−C(30) Sector

The richly oxygenated C(1)−C(30) polyol segment of amphidinol 3 has been synthesized in protected form. Incorporated in this long chain are 10 of the 25 stereogenic centers housed in the target. The asymmetric pathway that has been developed is based on the efficient union of three independently pre...

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Veröffentlicht in:Organic letters 2005-07, Vol.7 (14), p.3111-3114
Hauptverfasser: Paquette, Leo A, Chang, Shuh-Kuen
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemical synthesis
Alkenes - chemistry
Animals
Dinoflagellida - chemistry
Malates - chemistry
Molecular Structure
Pyrans - chemical synthesis
Pyrans - chemistry
Stereoisomerism
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Zusammenfassung:The richly oxygenated C(1)−C(30) polyol segment of amphidinol 3 has been synthesized in protected form. Incorporated in this long chain are 10 of the 25 stereogenic centers housed in the target. The asymmetric pathway that has been developed is based on the efficient union of three independently prepared subunits.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0511833