Four new HLA class I alleles in Cauacasoids
: Four new HLA classical class I alleles in the three loci are described in Caucasian individuals. A*3012 was first suspected by an abnormal serologic pattern that would be explained by the single amino acid substitution at the A30‐specific Ser17. B*270505 differs from B*270502 in a silent substitu...
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Veröffentlicht in: | Tissue antigens 2005-07, Vol.66 (1), p.51-53 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | : Four new HLA classical class I alleles in the three loci are described in Caucasian individuals. A*3012 was first suspected by an abnormal serologic pattern that would be explained by the single amino acid substitution at the A30‐specific Ser17. B*270505 differs from B*270502 in a silent substitution at an up to now constant position in the B locus. B*3541 encodes for a new Cys at position 118 that has not been encountered in neither human nor primate alleles. Cw*0716 seems to be originated by a large‐scale interallelic recombination event between Cw*0701/*0706/*0718 and Cw*020202, giving rise to a new antigen‐binding cleft conformation. |
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ISSN: | 0001-2815 1399-0039 |
DOI: | 10.1111/j.1399-0039.2005.00421.x |