The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients

A common heterozygous leucine-rich repeat kinase 2 (LRRK2) mutation 6055G > A transition (G2019S) accounts for about 3–7% of familial Parkinson's disease (PD) and 1–1.6% sporadic PD in a number of European populations. To determine the prevalence of the G1019S mutation in our Asian populatio...

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Veröffentlicht in:	Neuroscience letters 2005-08, Vol.384 (3), p.327-329
Hauptverfasser:	Tan, E.K., Shen, H., Tan, L.C.S., Farrer, M., Yew, K., Chua, E., Jamora, R.D., Puvan, K., Puong, K.Y., Zhao, Y., Pavanni, R., Wong, M.C., Yih, Yuen, Skipper, L., Liu, Jian-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Asia - epidemiology Biological and medical sciences Biomarkers - metabolism Cohort Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Mutational Analysis - methods Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease - epidemiology Genetic Testing - methods Humans Incidence Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 LRRK2 Male Medical sciences Middle Aged Mutation Neurology Parkinson Disease - enzymology Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease Polymorphism, Genetic Prevalence Protein-Serine-Threonine Kinases - genetics Risk Assessment - methods Risk Factors Singapore - epidemiology Vertebrates: nervous system and sense organs
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