The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients

A common heterozygous leucine-rich repeat kinase 2 (LRRK2) mutation 6055G > A transition (G2019S) accounts for about 3–7% of familial Parkinson's disease (PD) and 1–1.6% sporadic PD in a number of European populations. To determine the prevalence of the G1019S mutation in our Asian populatio...

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Veröffentlicht in:	Neuroscience letters 2005-08, Vol.384 (3), p.327-329
Hauptverfasser:	Tan, E.K., Shen, H., Tan, L.C.S., Farrer, M., Yew, K., Chua, E., Jamora, R.D., Puvan, K., Puong, K.Y., Zhao, Y., Pavanni, R., Wong, M.C., Yih, Yuen, Skipper, L., Liu, Jian-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Asia - epidemiology Biological and medical sciences Biomarkers - metabolism Cohort Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Mutational Analysis - methods Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease - epidemiology Genetic Testing - methods Humans Incidence Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 LRRK2 Male Medical sciences Middle Aged Mutation Neurology Parkinson Disease - enzymology Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease Polymorphism, Genetic Prevalence Protein-Serine-Threonine Kinases - genetics Risk Assessment - methods Risk Factors Singapore - epidemiology Vertebrates: nervous system and sense organs
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Zusammenfassung:	A common heterozygous leucine-rich repeat kinase 2 (LRRK2) mutation 6055G > A transition (G2019S) accounts for about 3–7% of familial Parkinson's disease (PD) and 1–1.6% sporadic PD in a number of European populations. To determine the prevalence of the G1019S mutation in our Asian population, we conducted genetic analysis of this mutation in 1000 PD and healthy controls. The G2019S mutation was not detected in any of our study subjects. The prevalence of G2019S mutation is rare (
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2005.04.103