MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer

The genotype frequencies of MDR1 T-129C, C1236T, G2677A, T and C3435T SNPs were compared in 154 healthy Japanese and 100 healthy Caucasians to provide basic information on the interethnic differences of pharmacotherapeutic outcome. The variants were found at allelic frequencies of 5.5%, 65.6%, 16.6%...

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Veröffentlicht in:Drug metabolism and pharmacokinetics 2006-01, Vol.21 (2), p.126-132
Hauptverfasser: Komoto, Chiho, Nakamura, Tsutomu, Sakaeda, Toshiyuki, Kroetz, Deanna L., Yamada, Toshio, Omatsu, Hideaki, Koyama, Tatsuya, Okamura, Noboru, Miki, Ikuya, Tamura, Takao, Aoyama, Nobuo, Kasuga, Masato, Okumura, Katsuhiko
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Sprache:eng
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Zusammenfassung:The genotype frequencies of MDR1 T-129C, C1236T, G2677A, T and C3435T SNPs were compared in 154 healthy Japanese and 100 healthy Caucasians to provide basic information on the interethnic differences of pharmacotherapeutic outcome. The variants were found at allelic frequencies of 5.5%, 65.6%, 16.6%, 40.6% and 40.6%, for T-129C, C1236T, G2677A, G2677T and C3435T, respectively, in Japanese, and at 5.1%, 45.9%, 3.6%, 46.4% and 56.6%, respectively, in Caucasians, with a statistically significant difference for C1236T, G2677A,T and C3435T (p
ISSN:1347-4367
1880-0920
DOI:10.2133/dmpk.21.126