Evidence-Based Incorporation of Serum Sodium Concentration Into MELD

Background & Aims: Serum sodium (Na) concentrations have been suggested as a useful predictor of mortality in patients with end-stage liver disease awaiting liver transplantation. Methods: We evaluated methods to incorporate Na into model for end-stage liver disease (MELD), using a prospective,...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2006-05, Vol.130 (6), p.1652-1660
Hauptverfasser:	Biggins, Scott W., Kim, W. Ray, Terrault, Norah A., Saab, Sammy, Balan, Vijay, Schiano, Thomas, Benson, Joanne, Therneau, Terry, Kremers, Walter, Wiesner, Russell, Kamath, Patrick, Klintmalm, Goran
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Biomarkers - blood Cause of Death Critical Illness Evidence-Based Medicine Female Humans Hyponatremia - diagnosis Liver Failure - diagnosis Liver Failure - mortality Liver Failure - surgery Liver Function Tests Liver Transplantation Male Predictive Value of Tests Proportional Hazards Models Prospective Studies Risk Assessment Sensitivity and Specificity Sodium - blood Sodium - metabolism Survival Analysis Waiting Lists
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Zusammenfassung:	Background & Aims: Serum sodium (Na) concentrations have been suggested as a useful predictor of mortality in patients with end-stage liver disease awaiting liver transplantation. Methods: We evaluated methods to incorporate Na into model for end-stage liver disease (MELD), using a prospective, multicenter database specifically created for validation and refinement of MELD. Adult, primary liver transplant candidates with end-stage liver disease were enrolled. Results: Complete data were available in 753 patients, in whom the median MELD score was 10.8 and sodium was 137 mEq/L. Low Na (
ISSN:	0016-5085 1528-0012
DOI:	10.1053/j.gastro.2006.02.010