Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-06, Vol.68 (6), p.853-857
Hauptverfasser:	Appendino, G, Aviello, G, Ballero, M, Borrelli, F, Fattorusso, E, Petrucci, F, Santelia, F.U, Taglialatela-Scafati, O
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Asteraceae - chemistry Biological and medical sciences cell lines chemical structure cytotoxicity Drug Screening Assays, Antitumor General pharmacology germacrane Humans Italy Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Santolina Santolina insularis Sesquiterpenes, Germacrane - chemistry Sesquiterpenes, Germacrane - isolation & purification Sesquiterpenes, Germacrane - pharmacology sesquiterpenoids spectral analysis stereochemistry Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np050120q