(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors
A novel series of imidazo[4,5- c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1 (MSK-1), and exemplified by the potent inhibitor 9. A novel series of imidazo[4,5- c]pyridines bearing a 1,2,5...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2005-07, Vol.15 (14), p.3402-3406 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Bamford, Mark J. Alberti, Michael J. Bailey, Nicholas Davies, Susannah Dean, David K. Gaiba, Alessandra Garland, Stephen Harling, John D. Jung, David K. Panchal, Terence A. Parr, Christopher A. Steadman, Jon G. Takle, Andrew K. Townsend, James T. Wilson, David M. Witherington, Jason |
| description | A novel series of imidazo[4,5-
c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1 (MSK-1), and exemplified by the potent inhibitor
9.
A novel series of imidazo[4,5-
c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1. |
| doi_str_mv | 10.1016/j.bmcl.2005.05.021 |
| format | Article |
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c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1 (MSK-1), and exemplified by the potent inhibitor
9.
A novel series of imidazo[4,5-
c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2005.05.021</identifier><identifier>PMID: 15950465</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amines - chemical synthesis ; Amines - classification ; Amines - pharmacology ; Biological and medical sciences ; Enzyme Inhibitors - chemical synthesis ; Enzyme Inhibitors - classification ; Enzyme Inhibitors - pharmacology ; Imidazo[4,5- c]pyridine ; Imidazoles - chemical synthesis ; Imidazoles - classification ; Imidazoles - pharmacology ; Medical sciences ; Miscellaneous ; Mitogen and stress-activated protein kinase ; Molecular Structure ; MSK-1 ; Oxadiazoles - chemical synthesis ; Oxadiazoles - classification ; Oxadiazoles - pharmacology ; Pharmacology. Drug treatments ; Pyridines - chemical synthesis ; Pyridines - classification ; Pyridines - pharmacology ; Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3402-3406</ispartof><rights>2005</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-c78835798e8f25cededf2c4f3b3f4920366a660887a635605051458da52614293</citedby><cites>FETCH-LOGICAL-c384t-c78835798e8f25cededf2c4f3b3f4920366a660887a635605051458da52614293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X05006086$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16903896$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15950465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bamford, Mark J.</creatorcontrib><creatorcontrib>Alberti, Michael J.</creatorcontrib><creatorcontrib>Bailey, Nicholas</creatorcontrib><creatorcontrib>Davies, Susannah</creatorcontrib><creatorcontrib>Dean, David K.</creatorcontrib><creatorcontrib>Gaiba, Alessandra</creatorcontrib><creatorcontrib>Garland, Stephen</creatorcontrib><creatorcontrib>Harling, John D.</creatorcontrib><creatorcontrib>Jung, David K.</creatorcontrib><creatorcontrib>Panchal, Terence A.</creatorcontrib><creatorcontrib>Parr, Christopher A.</creatorcontrib><creatorcontrib>Steadman, Jon G.</creatorcontrib><creatorcontrib>Takle, Andrew K.</creatorcontrib><creatorcontrib>Townsend, James T.</creatorcontrib><creatorcontrib>Wilson, David M.</creatorcontrib><creatorcontrib>Witherington, Jason</creatorcontrib><title>(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A novel series of imidazo[4,5-
c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1 (MSK-1), and exemplified by the potent inhibitor
9.
A novel series of imidazo[4,5-
c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.</description><subject>Amines - chemical synthesis</subject><subject>Amines - classification</subject><subject>Amines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Enzyme Inhibitors - chemical synthesis</subject><subject>Enzyme Inhibitors - classification</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Imidazo[4,5- c]pyridine</subject><subject>Imidazoles - chemical synthesis</subject><subject>Imidazoles - classification</subject><subject>Imidazoles - pharmacology</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mitogen and stress-activated protein kinase</subject><subject>Molecular Structure</subject><subject>MSK-1</subject><subject>Oxadiazoles - chemical synthesis</subject><subject>Oxadiazoles - classification</subject><subject>Oxadiazoles - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyridines - chemical synthesis</subject><subject>Pyridines - classification</subject><subject>Pyridines - pharmacology</subject><subject>Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors</subject><subject>Structure-Activity Relationship</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1rVDEQhoModm39A15IbhSFZpvvTYo3pVRbWvFCBUEkZJMczJJzsk3OLt3-enPYhd4JAwPD8w4zDwBvCJ4TTOTZar7sXZpTjMV8KkqegRnhkiPGsXgOZlhLjJTmv47Aq1pXGBOOOX8JjojQAnMpZuD-A4HX6KaP3j7m3_xUIOj-rHcl-jgginbpIyKntI3zg_WxMQmxNrV9HAL0ocStHeM21HN4AYe8DQm6ZGuFuYPrPIZhhF-_3yKC4vA3LuOYSz0BLzqbanh96Mfg5-erH5fX6O7bl5vLizvkmOIjcgulmFhoFVRHhQs--I463rEl67immElppcRKLaxkQmKBBeFCeSuoJJxqdgze7_euS77fhDqaPlYXUrJDyJtq5EJLyQhvIN2DruRaS-jMusTelp0h2EyizcpMos0k2kxFSQu9PWzfLPvgnyIHsw14dwBsdTZ1xQ4u1idOasyUlo37tOdCc7GNoZjqYhjaw7EENxqf4__u-AeQxJgx</recordid><startdate>20050715</startdate><enddate>20050715</enddate><creator>Bamford, Mark J.</creator><creator>Alberti, Michael J.</creator><creator>Bailey, Nicholas</creator><creator>Davies, Susannah</creator><creator>Dean, David K.</creator><creator>Gaiba, Alessandra</creator><creator>Garland, Stephen</creator><creator>Harling, John D.</creator><creator>Jung, David K.</creator><creator>Panchal, Terence A.</creator><creator>Parr, Christopher A.</creator><creator>Steadman, Jon G.</creator><creator>Takle, Andrew K.</creator><creator>Townsend, James T.</creator><creator>Wilson, David M.</creator><creator>Witherington, Jason</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050715</creationdate><title>(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors</title><author>Bamford, Mark J. ; Alberti, Michael J. ; Bailey, Nicholas ; Davies, Susannah ; Dean, David K. ; Gaiba, Alessandra ; Garland, Stephen ; Harling, John D. ; Jung, David K. ; Panchal, Terence A. ; Parr, Christopher A. ; Steadman, Jon G. ; Takle, Andrew K. ; Townsend, James T. ; Wilson, David M. ; Witherington, Jason</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-c78835798e8f25cededf2c4f3b3f4920366a660887a635605051458da52614293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amines - chemical synthesis</topic><topic>Amines - classification</topic><topic>Amines - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Enzyme Inhibitors - chemical synthesis</topic><topic>Enzyme Inhibitors - classification</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Imidazo[4,5- c]pyridine</topic><topic>Imidazoles - chemical synthesis</topic><topic>Imidazoles - classification</topic><topic>Imidazoles - pharmacology</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Mitogen and stress-activated protein kinase</topic><topic>Molecular Structure</topic><topic>MSK-1</topic><topic>Oxadiazoles - chemical synthesis</topic><topic>Oxadiazoles - classification</topic><topic>Oxadiazoles - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyridines - chemical synthesis</topic><topic>Pyridines - classification</topic><topic>Pyridines - pharmacology</topic><topic>Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bamford, Mark J.</creatorcontrib><creatorcontrib>Alberti, Michael J.</creatorcontrib><creatorcontrib>Bailey, Nicholas</creatorcontrib><creatorcontrib>Davies, Susannah</creatorcontrib><creatorcontrib>Dean, David K.</creatorcontrib><creatorcontrib>Gaiba, Alessandra</creatorcontrib><creatorcontrib>Garland, Stephen</creatorcontrib><creatorcontrib>Harling, John D.</creatorcontrib><creatorcontrib>Jung, David K.</creatorcontrib><creatorcontrib>Panchal, Terence A.</creatorcontrib><creatorcontrib>Parr, Christopher A.</creatorcontrib><creatorcontrib>Steadman, Jon G.</creatorcontrib><creatorcontrib>Takle, Andrew K.</creatorcontrib><creatorcontrib>Townsend, James T.</creatorcontrib><creatorcontrib>Wilson, David M.</creatorcontrib><creatorcontrib>Witherington, Jason</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bamford, Mark J.</au><au>Alberti, Michael J.</au><au>Bailey, Nicholas</au><au>Davies, Susannah</au><au>Dean, David K.</au><au>Gaiba, Alessandra</au><au>Garland, Stephen</au><au>Harling, John D.</au><au>Jung, David K.</au><au>Panchal, Terence A.</au><au>Parr, Christopher A.</au><au>Steadman, Jon G.</au><au>Takle, Andrew K.</au><au>Townsend, James T.</au><au>Wilson, David M.</au><au>Witherington, Jason</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2005-07-15</date><risdate>2005</risdate><volume>15</volume><issue>14</issue><spage>3402</spage><epage>3406</epage><pages>3402-3406</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>A novel series of imidazo[4,5-
c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1 (MSK-1), and exemplified by the potent inhibitor
9.
A novel series of imidazo[4,5-
c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15950465</pmid><doi>10.1016/j.bmcl.2005.05.021</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3402-3406 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amines - chemical synthesis Amines - classification Amines - pharmacology Biological and medical sciences Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - classification Enzyme Inhibitors - pharmacology Imidazo[4,5- c]pyridine Imidazoles - chemical synthesis Imidazoles - classification Imidazoles - pharmacology Medical sciences Miscellaneous Mitogen and stress-activated protein kinase Molecular Structure MSK-1 Oxadiazoles - chemical synthesis Oxadiazoles - classification Oxadiazoles - pharmacology Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - classification Pyridines - pharmacology Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors Structure-Activity Relationship |
| title | (1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors |
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