(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors

A novel series of imidazo[4,5- c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1 (MSK-1), and exemplified by the potent inhibitor 9. A novel series of imidazo[4,5- c]pyridines bearing a 1,2,5...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-07, Vol.15 (14), p.3402-3406
Hauptverfasser:	Bamford, Mark J., Alberti, Michael J., Bailey, Nicholas, Davies, Susannah, Dean, David K., Gaiba, Alessandra, Garland, Stephen, Harling, John D., Jung, David K., Panchal, Terence A., Parr, Christopher A., Steadman, Jon G., Takle, Andrew K., Townsend, James T., Wilson, David M., Witherington, Jason
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemical synthesis Amines - classification Amines - pharmacology Biological and medical sciences Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - classification Enzyme Inhibitors - pharmacology Imidazo[4,5- c]pyridine Imidazoles - chemical synthesis Imidazoles - classification Imidazoles - pharmacology Medical sciences Miscellaneous Mitogen and stress-activated protein kinase Molecular Structure MSK-1 Oxadiazoles - chemical synthesis Oxadiazoles - classification Oxadiazoles - pharmacology Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - classification Pyridines - pharmacology Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors Structure-Activity Relationship
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Zusammenfassung:	A novel series of imidazo[4,5- c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1 (MSK-1), and exemplified by the potent inhibitor 9. A novel series of imidazo[4,5- c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.05.021