Identification of aminopiperidine benzamides as MCHr1 antagonists

The identification of a novel series of benzamide-containing MCHr1 antagonists is described. The identification of a novel series of benzamide-containing MCHr1 antagonists is described. Compound 22 displayed moderate efficacy in a diet induced obesity mice model.

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-07, Vol.15 (14), p.3412-3416
Hauptverfasser:	Vasudevan, Anil, Verzal, Mary K., Wodka, Derek, Souers, Andrew J., Blackburn, Christopher, Che, Jennifer Lee, Lai, Sujen, Brodjian, Sevan, Falls, Doug H., Dayton, Brian D., Govek, Elizabeth, Daniels, Tom, Geddes, Brad, Marsh, Kennan C., Hernandez, Lisa E., Collins, Christine A., Kym, Philip R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Obesity Agents - chemical synthesis Anti-Obesity Agents - chemistry Anti-Obesity Agents - pharmacology Benzamides Benzamides - chemical synthesis Benzamides - chemistry Benzamides - pharmacology Binding, Competitive Biological and medical sciences Disease Models, Animal Dogs Hormones. Endocrine system MCH Medical sciences Melanin concentrating hormone Mice Molecular Structure Obesity Pharmacology. Drug treatments Piperidines - chemical synthesis Piperidines - chemistry Piperidines - pharmacology Receptors, Somatostatin - antagonists & inhibitors Receptors, Somatostatin - metabolism Structure-Activity Relationship Time Factors
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Beschreibung
Zusammenfassung:	The identification of a novel series of benzamide-containing MCHr1 antagonists is described. The identification of a novel series of benzamide-containing MCHr1 antagonists is described. Compound 22 displayed moderate efficacy in a diet induced obesity mice model.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.05.023