In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type

Altered expression of CCN3 has been observed in a variety of musculoskeletal tumours, including Ewing's sarcoma (ES). Despite its widespread distribution, very little is known about its biological functions and molecular mechanisms of action. We transfected CCN3 gene into a CCN3-negative ES cel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2005-06, Vol.24 (27), p.4349-4361
Hauptverfasser:	Benini, Stefania, Perbal, Bernard, Zambelli, Diana, Colombo, Mario Paolo, Manara, Maria Cristina, Serra, Massimo, Parenza, Mariella, Martinez, Vincent, Picci, Piero, Scotlandi, Katia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Bone cancer Cell Adhesion Cell Biology Cell Line Cell migration Cell Movement Cell physiology Cell Proliferation Cell surface Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Clone Cells - metabolism Clone Cells - pathology Collagen (type I) Connective Tissue Growth Factor Diseases of the osteoarticular system Ewing's sarcoma Ewings sarcoma Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Genes Glioblastoma Growth factors Human Genetics Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Internal Medicine Matrix metalloproteinase Matrix Metalloproteinases - metabolism Medical sciences Medicine Medicine & Public Health Metalloproteinase Mice Mice, Nude Molecular and cellular biology Molecular modelling Neoplasm Invasiveness Nephroblastoma Overexpressed Protein Oncology original-paper Proteins Receptor, IGF Type 1 - metabolism Receptor, Platelet-Derived Growth Factor alpha - metabolism Receptor, Platelet-Derived Growth Factor beta - metabolism Sarcoma, Ewing - genetics Sarcoma, Ewing - metabolism Sarcoma, Ewing - pathology Transfection Tumorigenicity Tumors Tumors of striated muscle and skeleton
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!