Dynamical Contributions to Enzyme Catalysis:  Critical Tests of A Popular Hypothesis

Dynamical Contributions to Enzyme Catalysis:  Critical Tests of A Popular Hypothesis

This review examines whether dynamical effects contribute significantly to enzyme catalysis. Computer simulations are used to address this question quantitatively.

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Veröffentlicht in:Chemical reviews 2006-05, Vol.106 (5), p.1737-1756
Hauptverfasser: Olsson, Mats H. M, Parson, William W, Warshel, Arieh
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Computer simulation
Enzyme Activation
Enzymes
Enzymes - chemistry
Hypotheses
Kinetics
Models, Chemical
Proteins
Solutions
Solvents
Structure-Activity Relationship
Substrate Specificity
Thermodynamics
Validation studies
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Zusammenfassung:This review examines whether dynamical effects contribute significantly to enzyme catalysis. Computer simulations are used to address this question quantitatively.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr040427e