Flaviviruses in motor neuron disease

Sporadic motor neuron disease (MND) causes a progressive loss of motor neurons. West Nile virus can attack motor neurons, so we examined whether flavivirus infection could be detected in MND cases. Spinal cord sections from 22 MND cases were stained immunohistochemically with a flavivirus‐specific a...

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Veröffentlicht in:	Muscle & nerve 2005-07, Vol.32 (1), p.108-109
Hauptverfasser:	Pamphlett, Roger, Kum-Jew, Stephen, King, Nicholas J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over amyotrophic lateral sclerosis Antibodies, Viral Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Flavivirus - immunology Flavivirus - isolation & purification flavivirus infection Flavivirus Infections - complications Flavivirus Infections - pathology Humans Immunohistochemistry Male Medical sciences Middle Aged motor neuron disease Motor Neuron Disease - pathology Motor Neuron Disease - virology muscular atrophy Neurology Spinal Cord - pathology Spinal Cord - virology West Nile virus
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Zusammenfassung:	Sporadic motor neuron disease (MND) causes a progressive loss of motor neurons. West Nile virus can attack motor neurons, so we examined whether flavivirus infection could be detected in MND cases. Spinal cord sections from 22 MND cases were stained immunohistochemically with a flavivirus‐specific antibody. No staining for flavivirus was seen in any case. Sporadic MND does not appear to arise from a recent infection with a flavivirus. Muscle Nerve, 2005
ISSN:	0148-639X 1097-4598
DOI:	10.1002/mus.20320