A Statistical Thermodynamic Model of the Protein Ensemble

A Statistical Thermodynamic Model of the Protein Ensemble

The background, physical basis, and the experimental validation of a structural thermodynamic model of the protein ensemble known as COREX is reviewed. The underpinnings of the COREX model are unique in that they were adopted for their simplicity.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical reviews 2006-05, Vol.106 (5), p.1545-1558
Hauptverfasser: Hilser, Vincent J, García-Moreno E, Bertrand, Oas, Terrence G, Kapp, Greg, Whitten, Steven T
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Kinetics
Models, Chemical
Models, Molecular
Models, Statistical
Molecular Structure
Protein Conformation
Proteins
Proteins - chemistry
Proteins - metabolism
Structure-Activity Relationship
Thermodynamics
Validation studies
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Beschreibung
Zusammenfassung:The background, physical basis, and the experimental validation of a structural thermodynamic model of the protein ensemble known as COREX is reviewed. The underpinnings of the COREX model are unique in that they were adopted for their simplicity.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr040423+