Synthesis of poly- O-sulfated glycosides of 2,5-anhydro- d-mannitol
[Display omitted] 2,5-Anhydro-3- O-β- d-glucopyranosyl-; -3- O-α- l-idopyranosyl-; -3- O-α- d-arabinopyranosyl-; -3- O-α- l-arabinopyranosyl-; -3- O-β- d-maltopyranosyl-; -3- O-β- d-gentiobiopyranosyl-; -1,6-di- O-β- d-glucopyranosyl-; -1,6-di- O-α- l-idopyranosyl-; -1- O-β- d-maltopyranosyl-; -1,3,...
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| Veröffentlicht in: | Carbohydrate research 2005-07, Vol.340 (10), p.1739-1749 |
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| container_end_page | 1749 |
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| container_issue | 10 |
| container_start_page | 1739 |
| container_title | Carbohydrate research |
| container_volume | 340 |
| creator | Kuszmann, János Medgyes, Gábor Boros, Sándor |
| description | [Display omitted]
2,5-Anhydro-3-
O-β-
d-glucopyranosyl-; -3-
O-α-
l-idopyranosyl-; -3-
O-α-
d-arabinopyranosyl-; -3-
O-α-
l-arabinopyranosyl-; -3-
O-β-
d-maltopyranosyl-; -3-
O-β-
d-gentiobiopyranosyl-; -1,6-di-
O-β-
d-glucopyranosyl-; -1,6-di-
O-α-
l-idopyranosyl-; -1-
O-β-
d-maltopyranosyl-; -1,3,6-tri-
O-β-
d-glucopyranosyl-; -1,6-di-
O-β-maltopyranosyl- and -1,6-di-
O-β-
d-gentiobiopyranosyl-2,5-anhydro-
d-mannitol as well as their poly-
O-sulfated derivatives were synthesized. The IP
3–IC
50 values of their sodium and/or potassium salts were determined for structure–activity studies aiming at the synthesis of new, orally active antiasthmatic compounds. |
| doi_str_mv | 10.1016/j.carres.2005.05.006 |
| format | Article |
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2,5-Anhydro-3-
O-β-
d-glucopyranosyl-; -3-
O-α-
l-idopyranosyl-; -3-
O-α-
d-arabinopyranosyl-; -3-
O-α-
l-arabinopyranosyl-; -3-
O-β-
d-maltopyranosyl-; -3-
O-β-
d-gentiobiopyranosyl-; -1,6-di-
O-β-
d-glucopyranosyl-; -1,6-di-
O-α-
l-idopyranosyl-; -1-
O-β-
d-maltopyranosyl-; -1,3,6-tri-
O-β-
d-glucopyranosyl-; -1,6-di-
O-β-maltopyranosyl- and -1,6-di-
O-β-
d-gentiobiopyranosyl-2,5-anhydro-
d-mannitol as well as their poly-
O-sulfated derivatives were synthesized. The IP
3–IC
50 values of their sodium and/or potassium salts were determined for structure–activity studies aiming at the synthesis of new, orally active antiasthmatic compounds.</description><identifier>ISSN: 0008-6215</identifier><identifier>EISSN: 1873-426X</identifier><identifier>DOI: 10.1016/j.carres.2005.05.006</identifier><identifier>PMID: 15953593</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>2,5-Anhydro- d-mannitol derivatives ; Antiasthmatic compounds ; Glycosides - chemical synthesis ; Glycosides - chemistry ; Mannitol - analogs & derivatives ; Mannitol - chemical synthesis ; Mannitol - chemistry ; Molecular Structure ; Mono-, di-, tri-, tetra- and pentasaccharides ; Poly- O-sulfated saccharides ; Sulfates - chemistry</subject><ispartof>Carbohydrate research, 2005-07, Vol.340 (10), p.1739-1749</ispartof><rights>2005 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-98810e0a0a7c11b6406d30e8b59c6b40003a0962664df397cb0b18bcd0cbe4db3</citedby><cites>FETCH-LOGICAL-c360t-98810e0a0a7c11b6406d30e8b59c6b40003a0962664df397cb0b18bcd0cbe4db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carres.2005.05.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15953593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuszmann, János</creatorcontrib><creatorcontrib>Medgyes, Gábor</creatorcontrib><creatorcontrib>Boros, Sándor</creatorcontrib><title>Synthesis of poly- O-sulfated glycosides of 2,5-anhydro- d-mannitol</title><title>Carbohydrate research</title><addtitle>Carbohydr Res</addtitle><description>[Display omitted]
2,5-Anhydro-3-
O-β-
d-glucopyranosyl-; -3-
O-α-
l-idopyranosyl-; -3-
O-α-
d-arabinopyranosyl-; -3-
O-α-
l-arabinopyranosyl-; -3-
O-β-
d-maltopyranosyl-; -3-
O-β-
d-gentiobiopyranosyl-; -1,6-di-
O-β-
d-glucopyranosyl-; -1,6-di-
O-α-
l-idopyranosyl-; -1-
O-β-
d-maltopyranosyl-; -1,3,6-tri-
O-β-
d-glucopyranosyl-; -1,6-di-
O-β-maltopyranosyl- and -1,6-di-
O-β-
d-gentiobiopyranosyl-2,5-anhydro-
d-mannitol as well as their poly-
O-sulfated derivatives were synthesized. The IP
3–IC
50 values of their sodium and/or potassium salts were determined for structure–activity studies aiming at the synthesis of new, orally active antiasthmatic compounds.</description><subject>2,5-Anhydro- d-mannitol derivatives</subject><subject>Antiasthmatic compounds</subject><subject>Glycosides - chemical synthesis</subject><subject>Glycosides - chemistry</subject><subject>Mannitol - analogs & derivatives</subject><subject>Mannitol - chemical synthesis</subject><subject>Mannitol - chemistry</subject><subject>Molecular Structure</subject><subject>Mono-, di-, tri-, tetra- and pentasaccharides</subject><subject>Poly- O-sulfated saccharides</subject><subject>Sulfates - chemistry</subject><issn>0008-6215</issn><issn>1873-426X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UE1Lw0AQXUSxtfoPRHLy5NbZfGySiyDFLyj0oIK3ZT8mdkuarbuJkH9vYgvehIFhmPfezHuEXDKYM2D8djPX0nsM8xggm48F_IhMWZEnNI35xzGZAkBBecyyCTkLYTOMwHN-SiYsK7MkK5MpWbz2TbvGYEPkqmjn6p5GKxq6upItmuiz7rUL1uDvOr7JqGzWvfGORoZuZdPY1tXn5KSSdcCLQ5-R98eHt8UzXa6eXhb3S6oTDi0ti4IBggSZa8YUT4GbBLBQWam5SofnEgkljzlPTZWUuVagWKG0Aa0wNSqZkeu97s67rw5DK7Y2aKxr2aDrguB5mQ3GygGY7oHauxA8VmLn7Vb6XjAQY3hiI_bhiTE8MRbwgXZ10O_UFs0f6ZDWALjbA3Bw-W3Ri6AtNhqN9ahbYZz9_8IPK-2A_A</recordid><startdate>20050725</startdate><enddate>20050725</enddate><creator>Kuszmann, János</creator><creator>Medgyes, Gábor</creator><creator>Boros, Sándor</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050725</creationdate><title>Synthesis of poly- O-sulfated glycosides of 2,5-anhydro- d-mannitol</title><author>Kuszmann, János ; Medgyes, Gábor ; Boros, Sándor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-98810e0a0a7c11b6406d30e8b59c6b40003a0962664df397cb0b18bcd0cbe4db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>2,5-Anhydro- d-mannitol derivatives</topic><topic>Antiasthmatic compounds</topic><topic>Glycosides - chemical synthesis</topic><topic>Glycosides - chemistry</topic><topic>Mannitol - analogs & derivatives</topic><topic>Mannitol - chemical synthesis</topic><topic>Mannitol - chemistry</topic><topic>Molecular Structure</topic><topic>Mono-, di-, tri-, tetra- and pentasaccharides</topic><topic>Poly- O-sulfated saccharides</topic><topic>Sulfates - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuszmann, János</creatorcontrib><creatorcontrib>Medgyes, Gábor</creatorcontrib><creatorcontrib>Boros, Sándor</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuszmann, János</au><au>Medgyes, Gábor</au><au>Boros, Sándor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of poly- O-sulfated glycosides of 2,5-anhydro- d-mannitol</atitle><jtitle>Carbohydrate research</jtitle><addtitle>Carbohydr Res</addtitle><date>2005-07-25</date><risdate>2005</risdate><volume>340</volume><issue>10</issue><spage>1739</spage><epage>1749</epage><pages>1739-1749</pages><issn>0008-6215</issn><eissn>1873-426X</eissn><abstract>[Display omitted]
2,5-Anhydro-3-
O-β-
d-glucopyranosyl-; -3-
O-α-
l-idopyranosyl-; -3-
O-α-
d-arabinopyranosyl-; -3-
O-α-
l-arabinopyranosyl-; -3-
O-β-
d-maltopyranosyl-; -3-
O-β-
d-gentiobiopyranosyl-; -1,6-di-
O-β-
d-glucopyranosyl-; -1,6-di-
O-α-
l-idopyranosyl-; -1-
O-β-
d-maltopyranosyl-; -1,3,6-tri-
O-β-
d-glucopyranosyl-; -1,6-di-
O-β-maltopyranosyl- and -1,6-di-
O-β-
d-gentiobiopyranosyl-2,5-anhydro-
d-mannitol as well as their poly-
O-sulfated derivatives were synthesized. The IP
3–IC
50 values of their sodium and/or potassium salts were determined for structure–activity studies aiming at the synthesis of new, orally active antiasthmatic compounds.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>15953593</pmid><doi>10.1016/j.carres.2005.05.006</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-6215 |
| ispartof | Carbohydrate research, 2005-07, Vol.340 (10), p.1739-1749 |
| issn | 0008-6215 1873-426X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67955959 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 2,5-Anhydro- d-mannitol derivatives Antiasthmatic compounds Glycosides - chemical synthesis Glycosides - chemistry Mannitol - analogs & derivatives Mannitol - chemical synthesis Mannitol - chemistry Molecular Structure Mono-, di-, tri-, tetra- and pentasaccharides Poly- O-sulfated saccharides Sulfates - chemistry |
| title | Synthesis of poly- O-sulfated glycosides of 2,5-anhydro- d-mannitol |
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