Synthesis of poly- O-sulfated glycosides of 2,5-anhydro- d-mannitol

[Display omitted] 2,5-Anhydro-3- O-β- d-glucopyranosyl-; -3- O-α- l-idopyranosyl-; -3- O-α- d-arabinopyranosyl-; -3- O-α- l-arabinopyranosyl-; -3- O-β- d-maltopyranosyl-; -3- O-β- d-gentiobiopyranosyl-; -1,6-di- O-β- d-glucopyranosyl-; -1,6-di- O-α- l-idopyranosyl-; -1- O-β- d-maltopyranosyl-; -1,3,6-tri- O-β- d-glucopyranosyl-; -1,6-di- O-β-maltopyranosyl- and -1,6-di- O-β- d-gentiobiopyranosyl-2,5-anhydro- d-mannitol as well as their poly- O-sulfated derivatives were synthesized. The IP 3–IC 50 values of their sodium and/or potassium salts were determined for structure–activity studies aiming at the synthesis of new, orally active antiasthmatic compounds.