Pathogenesis of liver involvement during dengue viral infections

The dengue virus can infect many cell types and cause diverse clinical and pathological effects. We describe clinical and experimental observations that suggest that liver involvement occurs during dengue infections, and we outline the possible role played by host immune responses in this process.

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Bibliographische Detailangaben
Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 2006-07, Vol.100 (7), p.608-614
Hauptverfasser:	Seneviratne, S.L., Malavige, G.N., de Silva, H.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - analysis Apoptosis - immunology Arboviroses Aspartate Aminotransferases - analysis B-Lymphocytes - immunology Biological and medical sciences Clinical observations Dengue Dengue - enzymology Dengue - immunology Dengue - virology Dengue fevers Dengue Virus - metabolism Hepatomegaly - virology Human viral diseases Humans Immune mechanisms Immunity - immunology Infectious diseases Liver Liver - enzymology Liver - immunology Liver - virology Liver Diseases - enzymology Liver Diseases - immunology Liver Diseases - virology Medical sciences T-Lymphocytes - immunology Transaminases Tropical viral diseases Viral diseases
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Beschreibung
Zusammenfassung:	The dengue virus can infect many cell types and cause diverse clinical and pathological effects. We describe clinical and experimental observations that suggest that liver involvement occurs during dengue infections, and we outline the possible role played by host immune responses in this process.
ISSN:	0035-9203 1878-3503
DOI:	10.1016/j.trstmh.2005.10.007