The pharmacokinetics of coagulation factors

The pharmacokinetics of coagulation factors

In this article, we provide a summary of the generally accepted approaches to the design and analysis of studies examining the pharmacokinetic (PK) profile of an infused coagulation factor in patients with a deficiency of one or more of these factors. Furthermore, we briefly review the known PK resu...

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Veröffentlicht in:Haemophilia : the official journal of the World Federation of Hemophilia 2006-07, Vol.12 (s3), p.1-7
Hauptverfasser: LEE, M., MORFINI, M., NEGRIER, C., CHAMOUARD, V.
Format: Artikel
Sprache:eng
Schlagworte:
Blood Coagulation Factors - pharmacokinetics
coagulation factor preparations
continuous infusion
Factor IX - pharmacokinetics
Factor VII - pharmacokinetics
Factor VIII - pharmacokinetics
Humans
pharmacokinetic studies
Recombinant Proteins - blood
Research Design
statistical design
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Beschreibung
Zusammenfassung:In this article, we provide a summary of the generally accepted approaches to the design and analysis of studies examining the pharmacokinetic (PK) profile of an infused coagulation factor in patients with a deficiency of one or more of these factors. Furthermore, we briefly review the known PK results for various commercially available coagulation factor preparations under single and continuous infusion.
ISSN:1351-8216
1365-2516
DOI:10.1111/j.1365-2516.2006.01253.x