Dose intensity of chemotherapy for osteosarcoma and outcome in the Cooperative Osteosarcoma Study Group (COSS) trials

Background The prognostic relevance of dose intensity in the treatment of osteosarcoma is still under discussion. The aim of this study was to investigate whether higher dose intensities of chemotherapy correlated with better outcomes. Procedure This study contains 917 consecutive Cooperative Osteos...

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Veröffentlicht in:	Pediatric Blood & Cancer 2006-07, Vol.47 (1), p.42-50
Hauptverfasser:	Eselgrim, Merle, Grunert, Henrike, Kühne, Thomas, Zoubek, Andreas, Kevric, Matthias, Bürger, Horst, Jürgens, Herbert, Mayer-Steinacker, Regine, Gosheger, Georg, Bielack, Stefan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Biological and medical sciences Bone Neoplasms - drug therapy Bone Neoplasms - pathology chemotherapy Child Child, Preschool Cisplatin - administration & dosage Disease-Free Survival dose intensity Dose-Response Relationship, Drug Doxorubicin - administration & dosage Female General aspects Humans Ifosfamide - administration & dosage Infant Male Medical sciences Methotrexate - administration & dosage Multivariate Analysis osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - pathology Proportional Hazards Models Retrospective Studies Survival Analysis Tumors
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Zusammenfassung:	Background The prognostic relevance of dose intensity in the treatment of osteosarcoma is still under discussion. The aim of this study was to investigate whether higher dose intensities of chemotherapy correlated with better outcomes. Procedure This study contains 917 consecutive Cooperative Osteosarcoma Study Group (COSS) patients
ISSN:	1545-5009 1545-5017 1096-911X
DOI:	10.1002/pbc.20608