Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer
In light to association of increased platelet glycoprotein Ia ( GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C 807/T 807), affecting the GPIa gene expression, in the development of oral cancer. DNA...
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| Veröffentlicht in: | European journal of surgical oncology 2006-05, Vol.32 (4), p.455-457 |
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| container_title | European journal of surgical oncology |
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| creator | Vairaktaris, E. Yapijakis, C. Derka, S. Vassiliou, S. Serefoglou, Z. Vylliotis, A. Wiltfang, J. Springer, I. Nkenke, E. Kessler, P. Neukam, F.W. |
| description | In light to association of increased platelet glycoprotein Ia (
GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C
807/T
807), affecting the
GPIa gene expression, in the development of oral cancer.
DNA samples of 110 patients with oral cancer and 114 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis.
The mutant T
807 allele homozygotes were significantly increased in the group of patients compared to the control group (
P |
| doi_str_mv | 10.1016/j.ejso.2005.12.005 |
| format | Article |
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GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C
807/T
807), affecting the
GPIa gene expression, in the development of oral cancer.
DNA samples of 110 patients with oral cancer and 114 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis.
The mutant T
807 allele homozygotes were significantly increased in the group of patients compared to the control group (
P<0.001). Furthermore, significantly increased frequency of mutant alleles compared to controls was observed in the subgroup of patients with a positive history for cancer (
P<0.01).
The obtained results indicate that the C
807/T
807 polymorphism is indeed a genetic predisposing factor which contributes to increased risk for oral cancer.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2005.12.005</identifier><identifier>PMID: 16513317</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alleles ; DNA, Neoplasm - genetics ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Genotype ; Glycoprotein GPIa ; Humans ; In Vitro Techniques ; Integrin alpha2 - genetics ; Integrin alpha2 - metabolism ; Mouth Neoplasms - blood ; Mouth Neoplasms - genetics ; Mouth Neoplasms - pathology ; Mutation ; Oncogenesis ; Oral cancer ; Polymerase Chain Reaction ; Polymorphism ; Polymorphism, Genetic ; Retrospective Studies ; α 2β 1 integrin</subject><ispartof>European journal of surgical oncology, 2006-05, Vol.32 (4), p.455-457</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c269t-79036e464745660af9788e9c33d769ef384db9cda861de00af8d436f076284743</citedby><cites>FETCH-LOGICAL-c269t-79036e464745660af9788e9c33d769ef384db9cda861de00af8d436f076284743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0748798305003495$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16513317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vairaktaris, E.</creatorcontrib><creatorcontrib>Yapijakis, C.</creatorcontrib><creatorcontrib>Derka, S.</creatorcontrib><creatorcontrib>Vassiliou, S.</creatorcontrib><creatorcontrib>Serefoglou, Z.</creatorcontrib><creatorcontrib>Vylliotis, A.</creatorcontrib><creatorcontrib>Wiltfang, J.</creatorcontrib><creatorcontrib>Springer, I.</creatorcontrib><creatorcontrib>Nkenke, E.</creatorcontrib><creatorcontrib>Kessler, P.</creatorcontrib><creatorcontrib>Neukam, F.W.</creatorcontrib><title>Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>In light to association of increased platelet glycoprotein Ia (
GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C
807/T
807), affecting the
GPIa gene expression, in the development of oral cancer.
DNA samples of 110 patients with oral cancer and 114 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis.
The mutant T
807 allele homozygotes were significantly increased in the group of patients compared to the control group (
P<0.001). Furthermore, significantly increased frequency of mutant alleles compared to controls was observed in the subgroup of patients with a positive history for cancer (
P<0.01).
The obtained results indicate that the C
807/T
807 polymorphism is indeed a genetic predisposing factor which contributes to increased risk for oral cancer.</description><subject>Alleles</subject><subject>DNA, Neoplasm - genetics</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glycoprotein GPIa</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Integrin alpha2 - genetics</subject><subject>Integrin alpha2 - metabolism</subject><subject>Mouth Neoplasms - blood</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mutation</subject><subject>Oncogenesis</subject><subject>Oral cancer</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Retrospective Studies</subject><subject>α 2β 1 integrin</subject><issn>0748-7983</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEYRYMotlZfwIVk5a5jMpnJD7gpxZ9CwY2uY5r5xqbOTMZkqvTtTWnBnasL4dzLl4PQNSUZJZTfbTLYRJ_lhJQZzbMUJ2hMS5ZPc1qKUzQmopBToSQboYsYN4QQxYQ6RyPKS8oYFWP0PovRW2cG5zvsa9w3ZoAGBvzR7Kzvgx_AdXhhcO-bXetDv3axxT9uWOPWdT5g19kAJsK-HFz8xHV69ME02JrOQrhEZ7VpIlwdc4LeHh9e58_T5cvTYj5bTm3O1ZCuJIxDwQtRlJwTUyshJSjLWCW4gprJolopWxnJaQUkAbIqGK-J4LlMJTZBt4fddPPXFuKgWxctNI3pwG-j5kIVQhY0gfkBtMHHGKDWfXCtCTtNid571Ru996r3XjXNdYpUujmub1ctVH-Vo8gE3B8ASH_8dhB0tA6SgMoFsIOuvPtv_xesL4oZ</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Vairaktaris, E.</creator><creator>Yapijakis, C.</creator><creator>Derka, S.</creator><creator>Vassiliou, S.</creator><creator>Serefoglou, Z.</creator><creator>Vylliotis, A.</creator><creator>Wiltfang, J.</creator><creator>Springer, I.</creator><creator>Nkenke, E.</creator><creator>Kessler, P.</creator><creator>Neukam, F.W.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer</title><author>Vairaktaris, E. ; Yapijakis, C. ; Derka, S. ; Vassiliou, S. ; Serefoglou, Z. ; Vylliotis, A. ; Wiltfang, J. ; Springer, I. ; Nkenke, E. ; Kessler, P. ; Neukam, F.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c269t-79036e464745660af9788e9c33d769ef384db9cda861de00af8d436f076284743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alleles</topic><topic>DNA, Neoplasm - genetics</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glycoprotein GPIa</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Integrin alpha2 - genetics</topic><topic>Integrin alpha2 - metabolism</topic><topic>Mouth Neoplasms - blood</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mutation</topic><topic>Oncogenesis</topic><topic>Oral cancer</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Retrospective Studies</topic><topic>α 2β 1 integrin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vairaktaris, E.</creatorcontrib><creatorcontrib>Yapijakis, C.</creatorcontrib><creatorcontrib>Derka, S.</creatorcontrib><creatorcontrib>Vassiliou, S.</creatorcontrib><creatorcontrib>Serefoglou, Z.</creatorcontrib><creatorcontrib>Vylliotis, A.</creatorcontrib><creatorcontrib>Wiltfang, J.</creatorcontrib><creatorcontrib>Springer, I.</creatorcontrib><creatorcontrib>Nkenke, E.</creatorcontrib><creatorcontrib>Kessler, P.</creatorcontrib><creatorcontrib>Neukam, F.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vairaktaris, E.</au><au>Yapijakis, C.</au><au>Derka, S.</au><au>Vassiliou, S.</au><au>Serefoglou, Z.</au><au>Vylliotis, A.</au><au>Wiltfang, J.</au><au>Springer, I.</au><au>Nkenke, E.</au><au>Kessler, P.</au><au>Neukam, F.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2006-05</date><risdate>2006</risdate><volume>32</volume><issue>4</issue><spage>455</spage><epage>457</epage><pages>455-457</pages><issn>0748-7983</issn><eissn>1532-2157</eissn><abstract>In light to association of increased platelet glycoprotein Ia (
GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C
807/T
807), affecting the
GPIa gene expression, in the development of oral cancer.
DNA samples of 110 patients with oral cancer and 114 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis.
The mutant T
807 allele homozygotes were significantly increased in the group of patients compared to the control group (
P<0.001). Furthermore, significantly increased frequency of mutant alleles compared to controls was observed in the subgroup of patients with a positive history for cancer (
P<0.01).
The obtained results indicate that the C
807/T
807 polymorphism is indeed a genetic predisposing factor which contributes to increased risk for oral cancer.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16513317</pmid><doi>10.1016/j.ejso.2005.12.005</doi><tpages>3</tpages></addata></record> |
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| ispartof | European journal of surgical oncology, 2006-05, Vol.32 (4), p.455-457 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alleles DNA, Neoplasm - genetics Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Genotype Glycoprotein GPIa Humans In Vitro Techniques Integrin alpha2 - genetics Integrin alpha2 - metabolism Mouth Neoplasms - blood Mouth Neoplasms - genetics Mouth Neoplasms - pathology Mutation Oncogenesis Oral cancer Polymerase Chain Reaction Polymorphism Polymorphism, Genetic Retrospective Studies α 2β 1 integrin |
| title | Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer |
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