Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer

In light to association of increased platelet glycoprotein Ia ( GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C 807/T 807), affecting the GPIa gene expression, in the development of oral cancer. DNA...

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Veröffentlicht in:	European journal of surgical oncology 2006-05, Vol.32 (4), p.455-457
Hauptverfasser:	Vairaktaris, E., Yapijakis, C., Derka, S., Vassiliou, S., Serefoglou, Z., Vylliotis, A., Wiltfang, J., Springer, I., Nkenke, E., Kessler, P., Neukam, F.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles DNA, Neoplasm - genetics Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Genotype Glycoprotein GPIa Humans In Vitro Techniques Integrin alpha2 - genetics Integrin alpha2 - metabolism Mouth Neoplasms - blood Mouth Neoplasms - genetics Mouth Neoplasms - pathology Mutation Oncogenesis Oral cancer Polymerase Chain Reaction Polymorphism Polymorphism, Genetic Retrospective Studies α 2β 1 integrin
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Zusammenfassung:	In light to association of increased platelet glycoprotein Ia ( GPIa) expression with tumor invasion and metastasis in several types of cancer, we investigated the possible contribution of a common polymorphism (C 807/T 807), affecting the GPIa gene expression, in the development of oral cancer. DNA samples of 110 patients with oral cancer and 114 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis. The mutant T 807 allele homozygotes were significantly increased in the group of patients compared to the control group ( P
ISSN:	0748-7983 1532-2157
DOI:	10.1016/j.ejso.2005.12.005