Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation
Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm–sap, a selective toxin for neurons that contain mu opioid...
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| Veröffentlicht in: | Brain research 2005-06, Vol.1048 (1), p.235-240 |
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| creator | Zhang, Rui-Xin Wang, Linbo Liu, Bing Qiao, Jian-Tian Ren, Ke Berman, Brian M. Lao, Lixing |
| description | Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm–sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia. |
| doi_str_mv | 10.1016/j.brainres.2005.05.008 |
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The present study demonstrates that pretreatment with Derm–sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2005.05.008</identifier><identifier>PMID: 15922310</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Acupuncture ; Analysis of Variance ; Animals ; Biological and medical sciences ; Blotting, Western - methods ; Dermorphin–saporin ; Electroacupuncture - methods ; Freund's Adjuvant - adverse effects ; Hindlimb - drug effects ; Hindlimb - innervation ; Hyperalgesia ; Hyperalgesia - etiology ; Hyperalgesia - therapy ; Immunohistochemistry - methods ; Inflammation - chemically induced ; Inflammation - complications ; Lectins - metabolism ; Male ; Medical sciences ; Miscellaneous ; N-Glycosyl Hydrolases ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Neurons - metabolism ; Opioid Peptides ; Pain ; Pain Measurement - methods ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Random Allocation ; Rat ; Rats ; Rats, Sprague-Dawley ; Reaction Time - drug effects ; Receptors, Opioid, delta - metabolism ; Receptors, Opioid, mu - metabolism ; Recombinant Fusion Proteins - pharmacology ; Ribosome Inactivating Proteins, Type 1 ; Skin - drug effects ; Skin - innervation ; Spinal cord ; Spinal Cord - cytology ; Spinal Cord - drug effects ; Spinal Cord - metabolism ; Substance P - metabolism</subject><ispartof>Brain research, 2005-06, Vol.1048 (1), p.235-240</ispartof><rights>2005 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-a2f1881edb6d3a7af520c43ac0249332e5610557082a3962d5557940d819d2a83</citedby><cites>FETCH-LOGICAL-c458t-a2f1881edb6d3a7af520c43ac0249332e5610557082a3962d5557940d819d2a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899305007195$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16884598$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15922310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Rui-Xin</creatorcontrib><creatorcontrib>Wang, Linbo</creatorcontrib><creatorcontrib>Liu, Bing</creatorcontrib><creatorcontrib>Qiao, Jian-Tian</creatorcontrib><creatorcontrib>Ren, Ke</creatorcontrib><creatorcontrib>Berman, Brian M.</creatorcontrib><creatorcontrib>Lao, Lixing</creatorcontrib><title>Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm–sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia.</description><subject>Acupuncture</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western - methods</subject><subject>Dermorphin–saporin</subject><subject>Electroacupuncture - methods</subject><subject>Freund's Adjuvant - adverse effects</subject><subject>Hindlimb - drug effects</subject><subject>Hindlimb - innervation</subject><subject>Hyperalgesia</subject><subject>Hyperalgesia - etiology</subject><subject>Hyperalgesia - therapy</subject><subject>Immunohistochemistry - methods</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - complications</subject><subject>Lectins - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>N-Glycosyl Hydrolases</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Opioid Peptides</subject><subject>Pain</subject><subject>Pain Measurement - methods</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Random Allocation</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reaction Time - drug effects</subject><subject>Receptors, Opioid, delta - metabolism</subject><subject>Receptors, Opioid, mu - metabolism</subject><subject>Recombinant Fusion Proteins - pharmacology</subject><subject>Ribosome Inactivating Proteins, Type 1</subject><subject>Skin - drug effects</subject><subject>Skin - innervation</subject><subject>Spinal cord</subject><subject>Spinal Cord - cytology</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - metabolism</subject><subject>Substance P - metabolism</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEQgBtR3HH1Lyy56K3HvDqdvimLL1jxoudQk1TvZOhJ2iTtshd_u2lmZI8DBaHCVw_qa5obRreMMvX-sN0l8CFh3nJKu-0aVD9rNkz3vFVc0ufNhlKqWj0M4qp5lfOhpkIM9GVzxbqBc8Hopvn7fSFx9tE7ktDiXGJqbQyl9vbhngRcUgyZHNF5KEhwQltSBLvMS7BlSdjOKbrFoiMQim_3jzMmmO4xeyA-kAQlkwdf9mTvgyMzPNTfcYLjEYqP4XXzYoQp45vze938-vzp5-3X9u7Hl2-3H-9aKztdWuAj05qh2yknoIex49RKAZZyOQjBsVOMdl1PNQcxKO66mgySOs0Gx0GL6-bdqW_d9veCuZijzxanCQLGJRtV6Z4reRHkVDOpxXARZL2QshfraHUCbYo5JxzNnPwR0qNh1KwuzcH8d2lWl2YNuhbenCcsu3r_p7KzvAq8PQOQLUxjgmB9fuKU1rIb1kYfThzWC__xmEy2HkN15qvzYlz0l3b5ByQZwlg</recordid><startdate>20050628</startdate><enddate>20050628</enddate><creator>Zhang, Rui-Xin</creator><creator>Wang, Linbo</creator><creator>Liu, Bing</creator><creator>Qiao, Jian-Tian</creator><creator>Ren, Ke</creator><creator>Berman, Brian M.</creator><creator>Lao, Lixing</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050628</creationdate><title>Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation</title><author>Zhang, Rui-Xin ; Wang, Linbo ; Liu, Bing ; Qiao, Jian-Tian ; Ren, Ke ; Berman, Brian M. ; Lao, Lixing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-a2f1881edb6d3a7af520c43ac0249332e5610557082a3962d5557940d819d2a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acupuncture</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western - methods</topic><topic>Dermorphin–saporin</topic><topic>Electroacupuncture - methods</topic><topic>Freund's Adjuvant - adverse effects</topic><topic>Hindlimb - drug effects</topic><topic>Hindlimb - innervation</topic><topic>Hyperalgesia</topic><topic>Hyperalgesia - etiology</topic><topic>Hyperalgesia - therapy</topic><topic>Immunohistochemistry - methods</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - complications</topic><topic>Lectins - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>N-Glycosyl Hydrolases</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Neurons - metabolism</topic><topic>Opioid Peptides</topic><topic>Pain</topic><topic>Pain Measurement - methods</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Random Allocation</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reaction Time - drug effects</topic><topic>Receptors, Opioid, delta - metabolism</topic><topic>Receptors, Opioid, mu - metabolism</topic><topic>Recombinant Fusion Proteins - pharmacology</topic><topic>Ribosome Inactivating Proteins, Type 1</topic><topic>Skin - drug effects</topic><topic>Skin - innervation</topic><topic>Spinal cord</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - metabolism</topic><topic>Substance P - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Rui-Xin</creatorcontrib><creatorcontrib>Wang, Linbo</creatorcontrib><creatorcontrib>Liu, Bing</creatorcontrib><creatorcontrib>Qiao, Jian-Tian</creatorcontrib><creatorcontrib>Ren, Ke</creatorcontrib><creatorcontrib>Berman, Brian M.</creatorcontrib><creatorcontrib>Lao, Lixing</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Rui-Xin</au><au>Wang, Linbo</au><au>Liu, Bing</au><au>Qiao, Jian-Tian</au><au>Ren, Ke</au><au>Berman, Brian M.</au><au>Lao, Lixing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2005-06-28</date><risdate>2005</risdate><volume>1048</volume><issue>1</issue><spage>235</spage><epage>240</epage><pages>235-240</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm–sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>15922310</pmid><doi>10.1016/j.brainres.2005.05.008</doi><tpages>6</tpages></addata></record> |
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| subjects | Acupuncture Analysis of Variance Animals Biological and medical sciences Blotting, Western - methods Dermorphin–saporin Electroacupuncture - methods Freund's Adjuvant - adverse effects Hindlimb - drug effects Hindlimb - innervation Hyperalgesia Hyperalgesia - etiology Hyperalgesia - therapy Immunohistochemistry - methods Inflammation - chemically induced Inflammation - complications Lectins - metabolism Male Medical sciences Miscellaneous N-Glycosyl Hydrolases Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neurons - metabolism Opioid Peptides Pain Pain Measurement - methods Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Random Allocation Rat Rats Rats, Sprague-Dawley Reaction Time - drug effects Receptors, Opioid, delta - metabolism Receptors, Opioid, mu - metabolism Recombinant Fusion Proteins - pharmacology Ribosome Inactivating Proteins, Type 1 Skin - drug effects Skin - innervation Spinal cord Spinal Cord - cytology Spinal Cord - drug effects Spinal Cord - metabolism Substance P - metabolism |
| title | Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation |
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