Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation

Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm–sap, a selective toxin for neurons that contain mu opioid...

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Veröffentlicht in:	Brain research 2005-06, Vol.1048 (1), p.235-240
Hauptverfasser:	Zhang, Rui-Xin, Wang, Linbo, Liu, Bing, Qiao, Jian-Tian, Ren, Ke, Berman, Brian M., Lao, Lixing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acupuncture Analysis of Variance Animals Biological and medical sciences Blotting, Western - methods Dermorphin–saporin Electroacupuncture - methods Freund's Adjuvant - adverse effects Hindlimb - drug effects Hindlimb - innervation Hyperalgesia Hyperalgesia - etiology Hyperalgesia - therapy Immunohistochemistry - methods Inflammation - chemically induced Inflammation - complications Lectins - metabolism Male Medical sciences Miscellaneous N-Glycosyl Hydrolases Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neurons - metabolism Opioid Peptides Pain Pain Measurement - methods Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Random Allocation Rat Rats Rats, Sprague-Dawley Reaction Time - drug effects Receptors, Opioid, delta - metabolism Receptors, Opioid, mu - metabolism Recombinant Fusion Proteins - pharmacology Ribosome Inactivating Proteins, Type 1 Skin - drug effects Skin - innervation Spinal cord Spinal Cord - cytology Spinal Cord - drug effects Spinal Cord - metabolism Substance P - metabolism
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Zusammenfassung:	Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm–sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2005.05.008