The Codon 47 Polymorphism in p53 Is Functionally Significant

The Codon 47 Polymorphism in p53 Is Functionally Significant

In addition to a common polymorphism at codon 72, the p53 tumor suppressor gene also contains a rare single nucleotide polymorphism at amino acid 47. Wild type p53 encodes proline at this residue, but in

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Bibliographische Detailangaben
Veröffentlicht in:The Journal of biological chemistry 2005-06, Vol.280 (25), p.24245-24251
Hauptverfasser: Li, Xiaoxian, Dumont, Patrick, Pietra, Anthony Della, Shetler, Cory, Murphy, Maureen E.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Base Sequence
Black or African American
Black People
Codon
DNA Primers
Humans
Molecular Sequence Data
p38 Mitogen-Activated Protein Kinases - metabolism
Polymorphism, Genetic
Tumor Suppressor Protein p53 - chemistry
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - physiology
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Zusammenfassung:In addition to a common polymorphism at codon 72, the p53 tumor suppressor gene also contains a rare single nucleotide polymorphism at amino acid 47. Wild type p53 encodes proline at this residue, but in
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.M414637200