Functional analysis of immune response genes in Drosophila identifies JNK pathway as a regulator of antimicrobial peptide gene expression in S2 cells

The templates of innate immunity have ancient origins. Thus, such model animals as the fruit fly, Drosophila melanogaster, can be used to identify gene products that also play a key role in the innate immunity in mammals. We have used oligonucleotide microarrays to identify genes that are responsive...

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Veröffentlicht in:	Microbes and infection 2005-05, Vol.7 (5), p.811-819
Hauptverfasser:	Kallio, Jenni, Leinonen, Anni, Ulvila, Johanna, Valanne, Susanna, Ezekowitz, R. Alan, Rämet, Mika
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - immunology Escherichia coli Escherichia coli - immunology Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation - immunology Genes, Insect Immunity, Innate - genetics Innate immunity JNK Mitogen-Activated Protein Kinases - physiology JNK signaling MAP Kinase Kinase 4 Microbiology Mitogen-Activated Protein Kinase Kinases - physiology
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