Regulating Supramolecular Function in Membranes: Calixarenes that Enable or Inhibit Transmembrane Cl− Transport

Regulating Supramolecular Function in Membranes: Calixarenes that Enable or Inhibit Transmembrane Cl− Transport

Self‐assembled transporter: Self‐association of a partial‐cone calixarene amide provides membrane‐active aggregates that enable the transport of chloride anions across phospholipid membranes (see picture). Additionally, a regulatory system is described, wherein an inactive calixarene analogue inhibi...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-05, Vol.45 (20), p.3334-3338
Hauptverfasser: Seganish, Jennifer L., Santacroce, Paul V., Salimian, Kevan J., Fettinger, James C., Zavalij, Peter, Davis, Jeffery T.
Format: Artikel
Sprache:eng
Schlagworte:
calixarenes
ion channels
ion transport
self-assembly
supramolecular chemistry
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Beschreibung
Zusammenfassung:Self‐assembled transporter: Self‐association of a partial‐cone calixarene amide provides membrane‐active aggregates that enable the transport of chloride anions across phospholipid membranes (see picture). Additionally, a regulatory system is described, wherein an inactive calixarene analogue inhibits the active chloride transporter.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200504489