Chiral Brønsted Acid Catalyzed Enantioselective Hydrophosphonylation of Imines:  Asymmetric Synthesis of α-Amino Phosphonates

Chiral Brønsted Acid Catalyzed Enantioselective Hydrophosphonylation of Imines:  Asymmetric Synthesis of α-Amino Phosphonates

A cyclic phosphoric acid derivative, derived from (R)-BINOL, was used as a chiral Brønsted acid (10 mol %) in hydrophosphonylation of aldimines with diisopropyl phosphite at room temperature. α-Amino phosphonates were obtained with good to high enantioselectivities.

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Veröffentlicht in:Organic letters 2005-06, Vol.7 (13), p.2583-2585
Hauptverfasser: Akiyama, Takahiko, Morita, Hisashi, Itoh, Junji, Fuchibe, Kohei
Format: Artikel
Sprache:eng
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Zusammenfassung:A cyclic phosphoric acid derivative, derived from (R)-BINOL, was used as a chiral Brønsted acid (10 mol %) in hydrophosphonylation of aldimines with diisopropyl phosphite at room temperature. α-Amino phosphonates were obtained with good to high enantioselectivities.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol050695e