Apomorphine-induced myocardial protection is due to antioxidant and not adrenergic/dopaminergic effects

Apomorphine-induced myocardial protection is due to antioxidant and not adrenergic/dopaminergic effects

Apomorphine (Apo), a dopaminergic agonist used for treatment of Parkinson disease, is a potent antioxidant. In addition to its antioxidative effects, the dopaminergic and adrenergic effects of Apo were studied. Isolated perfused rat hearts were exposed to 25 min of no-flow global ischemia (37°C) and...

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Veröffentlicht in:Free radical biology & medicine 2006-05, Vol.40 (10), p.1713-1720
Hauptverfasser: Khaliulin, Igor, Schneider, Aviva, Houminer, Esther, Borman, Joseph B., Schwalb, Herzl
Format: Artikel
Sprache:eng
Schlagworte:
Adrenergic Agents - pharmacology
Animals
Antioxidants - pharmacology
Apomorphine - pharmacology
Carbonyls
Dopamine Agents - pharmacology
Electrophoresis, Polyacrylamide Gel
Free radicals
Haloperidol
Haloperidol - pharmacology
Heart
Heart - drug effects
Hemodynamics - drug effects
Immunoblotting
Ischemia
l-DOPA
Levodopa - pharmacology
Male
Myocardial Reperfusion Injury - drug therapy
Propranolol
Propranolol - pharmacology
Rats
Rats, Sprague-Dawley
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Zusammenfassung:Apomorphine (Apo), a dopaminergic agonist used for treatment of Parkinson disease, is a potent antioxidant. In addition to its antioxidative effects, the dopaminergic and adrenergic effects of Apo were studied. Isolated perfused rat hearts were exposed to 25 min of no-flow global ischemia (37°C) and 60 min of reperfusion (I/R, control). Drugs were introduced for the first 20 min of reperfusion. The LVDP of the control group recovered to 54.6 ± 3.3%. Apo-treated hearts had significantly improved recovery (61.6 ± 5%, p 
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2006.01.001