Gene polymorphisms affecting HDL-cholesterol levels in the normolipidemic population

HDL-cholesterol (HDL-C) is inversely related to the risk of ischemic heart disease. Many genes are reported to affect HDL-C serum levels in both hyperlipidemic and normolipidemic populations, though the data are controversial. We examined the effect of common gene polymorphisms known to interfere wi...

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Veröffentlicht in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2005-06, Vol.15 (3), p.219-224
Hauptverfasser: Miltiadous, George, Hatzivassiliou, Marilena, Liberopoulos, Evagelos, Bairaktari, Eleni, Tselepis, Alexandros, Cariolou, Marios, Elisaf, Moses
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Sprache:eng
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Zusammenfassung:HDL-cholesterol (HDL-C) is inversely related to the risk of ischemic heart disease. Many genes are reported to affect HDL-C serum levels in both hyperlipidemic and normolipidemic populations, though the data are controversial. We examined the effect of common gene polymorphisms known to interfere with HDL-C metabolism (apolipoprotein E, cholesterol ester transfer protein and apolipoprotein A-IV gene polymorphisms) on HDL-C plasma levels in normolipidemic subjects. The study population consisted of 200 normolipidemic individuals visiting our clinic for a routine check-up. None of the above gene polymorphisms affected HDL-C levels in our population. However, participants carrying the allele E4 of the apolipoprotein (apo) E gene, the allele B1 of the TaqIB polymorphisms in the cholesterol ester transfer protein (CETP) gene and the allele T of the apoA-IV gene (A to T polymorphism at site 347) ( n=28) had statistically significantly lower HDL-C levels compared to those not carrying the above allele combination (0.99±0.33 vs 1.28±0.35 mmol/L, p=0.04). In this study, we describe a subgroup of normolipidemic individuals with low HDL-C levels due to genetic variability, and we discuss the underlying possible mechanisms involved.
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2004.09.004